Rabbit WBS16 Polyclonal Antibody | anti-WBS16 antibody

WBS16, NT (WBSCR16, Williams-Beuren syndrome chromosomal region 16 protein, RCC1-like G exchanging factor-like protein) (Azide free) (HRP)

Cat. Num. AAA6363042

• Gene Names: RCC1L; WBSCR16
• Reactivity: Hamster, Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: WBS16; Polyclonal Antibody; NT (WBSCR16; Williams-Beuren syndrome chromosomal region 16 protein; RCC1-like G exchanging factor-like protein) (Azide free) (HRP); WBSCR16; RCC1-like G exchanging factor-like protein; anti-WBS16 antibody

• Host: Rabbit
• Reactivity: Hamster, Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
• Sequence Length: 464

• Applicable Applications for anti-WBS16 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: WBS16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-44 amino acids from the N-terminal region of human WBS16.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(WBS16 Antibody (N-term) western blot analysis in CHO cell line lysates (35ug/lane).This demonstrates the WBS16 antibody detected the WBS16 protein (arrow).)

Related Product Information for anti-WBS16 antibody

This gene encodes an RCC1-like G-exchanging factor. It is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. [provided by RefSeq].

Product Categories/Family for anti-WBS16 antibody

Antibodies; Disease Markers

References

Merla, G., et al. Hum. Genet. 110(5):429-438(2002).

NCBI and Uniprot Product Information

• NCBI GI #: 13540582
• NCBI GeneID: 81554
• NCBI Accession #: NP_110425.1
• NCBI GenBank Nucleotide #: NP_110425.1
• UniProt Accession #: Q96I51
• NCBI Official Full Name: Williams-Beuren syndrome chromosomal region 16 protein
• NCBI Official Synonym Full Names: RCC1 like
• NCBI Official Symbol: RCC1L
• NCBI Official Synonym Symbols: WBSCR16
• NCBI Protein Information: RCC1-like G exchanging factor-like protein
• UniProt Protein Name: Williams-Beuren syndrome chromosomal region 16 protein
• UniProt Gene Name: WBSCR16
• UniProt Entry Name: WBS16_HUMAN

NCBI Description

This gene encodes a protein containing regulator of chromosome condensation 1-like repeats. The encoded protein may function as a guanine nucleotide exchange factor. This gene is located in a region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

Tissue specificity: Ubiquitous. Ref.1

Involvement in disease: WBSCR16 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR16 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Sequence similarities: Contains 6 RCC1 repeats.