Western Blot (WB)
(Western blot analysis of VNN3 in human brain tissue lysate with VNN3 antibody at (A) 0.5 and (B) 1 μg/mL.)
Rabbit VNN3 Polyclonal Antibody | anti-VNN3 antibody
VNN3 Antibody
Gene Names
VNN3; HSA238982
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
VNN3 Antibody is affinity chromatography purified via peptide column.
Synonyms
VNN3; Polyclonal Antibody; VNN3 Antibody; HSA238982; Vascular non-inflammatory molecule 3; Vanin-3; vanin 3; anti-VNN3 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Multiple isoforms of VNN3 are known to exist.
Purity/Purification
VNN3 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
501
Applicable Applications for anti-VNN3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
VNN3 antibody can be used for detection of VNN3 by Western blot at 0.5 and 1 mug/mL.
Conjugate
Unconjugated
Immunogen
VNN3 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human VNN3.
Buffer
VNN3 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
VNN3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of VNN3 in human brain tissue lysate with VNN3 antibody at (A) 0.5 and (B) 1 μg/mL.)
Western Blot (WB)
(Western blot analysis of VNN3 in human brain tissue lysate with VNN3 antibody at (A) 0.5 and (B) 1 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of VNN3 in human liver tissue with VNN3 antibody at 5 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of VNN3 in human liver tissue with VNN3 antibody at 5 μg/mL.)
Related Product Information for anti-VNN3 antibody
VNN3 Antibody: The vanin family is a novel group of ectoenzymes that function in tissue repair and plays a role in oxidative-stress response. As both secreted and membrane proteins, the vanin family members have been implicated as therapeutic targets in inflammatory disease. VNN3 (vascular non-inflammatory molecule 3), also known as Vanin3, is a 501 amino acid GPI-anchored amidohydrolase that is widely expressed and is found at highest levels in blood and liver. Induced by Th17 / Th1 type cytokines, VNN3 converts pantetheine into pantothenic acid. Containing one CN hydrolase domain, VNN3 is encoded by a gene that maps to human chromosome 6q23.2.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
55 kDa
NCBI Official Full Name
Vascular non-inflammatory molecule 3
NCBI Official Synonym Full Names
vanin 3
NCBI Official Symbol
VNN3
NCBI Official Synonym Symbols
HSA238982
NCBI Protein Information
vascular non-inflammatory molecule 3; vanin-3; vanin 1 pseudogene; pantetheinase pseudogene; pantetheinase-associated gene expressed in leukocytes (PAGEL)-alpha
UniProt Protein Name
Vascular non-inflammatory molecule 3
Protein Family
UniProt Gene Name
VNN3
UniProt Synonym Gene Names
Vanin-3
UniProt Entry Name
VNN3_HUMAN
NCBI Description
This gene is the central gene in a cluster of three vanin genes on chromosome 6q23-q24. Extensive alternative splicing has been described; the two most common variants are represented as RefSeqs. [provided by RefSeq, Apr 2014]
Uniprot Description
VNN3: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Belongs to the CN hydrolase family. BTD/VNN subfamily. Induced by Th17/Th1 type cytokines, but not by Th2-type. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.5.1.92; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 6q23.2
Cellular Component: plasma membrane
Molecular Function: pantetheine hydrolase activity
Biological Process: nitrogen compound metabolic process
Research Articles on VNN3
Similar Products
Product Notes
The VNN3 vnn3 (Catalog #AAA153472) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The VNN3 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's VNN3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). VNN3 antibody can be used for detection of VNN3 by Western blot at 0.5 and 1 mug/mL. Researchers should empirically determine the suitability of the VNN3 vnn3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VNN3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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