Rabbit anti-Human MYPN Polyclonal Antibody | anti-MYPN antibody

MYPN-Specific Rabbit Polyclonal

Cat. Num. AAA7601758

• Gene Names: MYPN; MYOP; RCM4; CMH22; CMD1DD
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunofluorescence, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: MYPN; Polyclonal Antibody; MYPN-Specific Rabbit Polyclonal; anti-MYPN antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 1320

• Applicable Applications for anti-MYPN antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
• Immunogen: Myopalladin
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using MBS7601758 (MYPN-Specific Antibody) at dilution of 1:50)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7601758 (MYPN-Specific antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 372220097
• NCBI GeneID: 84665
• NCBI Accession #: NP_001243196.1
• NCBI GenBank Nucleotide #: NM_001256267.1
• Molecular Weight: 56,185 Da
• NCBI Official Full Name: myopalladin isoform a
• NCBI Official Synonym Full Names: myopalladin
• NCBI Official Symbol: MYPN
• NCBI Official Synonym Symbols: MYOP; RCM4; CMH22; CMD1DD
• NCBI Protein Information: myopalladin
• UniProt Protein Name: Myopalladin
• Protein Family: Myopalladin
• UniProt Gene Name: MYPN
• UniProt Synonym Gene Names: MYOP
• UniProt Entry Name: MYPN_HUMAN

NCBI Description

Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Uniprot Description

MYPN: Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. Belongs to the myotilin/palladin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 10q21.3

Cellular Component: I band; nucleus; Z disc

Molecular Function: actin binding; cytoskeletal protein binding; muscle alpha-actinin binding; protein binding; SH3 domain binding

Biological Process: sarcomere organization

Disease: Cardiomyopathy, Dilated, 1kk