Rabbit anti-Rat Vasopressin Receptor, Arg, V1a Polyclonal Antibody | anti-Avpr1a antibody

Vasopressin Receptor, Arg, V1a (AVR-V1a)

Cat. Num. AAA613195

• Gene Names: Avpr1a; V1a; AVPR; V1aR; Avpr1
• Reactivity: Rat
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: Vasopressin Receptor; Arg; V1a; Polyclonal Antibody; V1a (AVR-V1a); Anti -Vasopressin Receptor; anti-Avpr1a antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: The 18 aa rat peptide has 100% sequence homology with rat AVP1a receptors (394, 395 and 424 aa) and 55% with mouse (10/18 aa) AVR-V1a receptors. Sequence homology of the peptide with the human AVR-V1a was not significant. No significant similarity is seen with AVP V1b or V2 or V3 receptors.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.1% BSA, 0.1% sodium azide, 40% glycerol.

• Applicable Applications for anti-Avpr1a antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 0.5-1ug/ml; Western Blot: 1-10ug/ml; Optimal dilutions to be determined by the researcher.
• Immunogen: An 18 aa peptide sequence within the cytoplasmic domain between the TM5 and TM6, selected for antibody. The peptide was synthesized as Cysteine at the NH2-terminus and coupled to KLH
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-Avpr1a antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 33149329
• NCBI GeneID: 54140
• NCBI Accession #: NP_058543.2
• NCBI GenBank Nucleotide #: NM_016847.2
• UniProt Accession #: Q3U1H9; Q3UEE1; Q62463
• Molecular Weight: 47,182 Da
• NCBI Official Full Name: vasopressin V1a receptor
• NCBI Official Synonym Full Names: arginine vasopressin receptor 1A
• NCBI Official Symbol: Avpr1a
• NCBI Official Synonym Symbols: V1a; AVPR; V1aR; Avpr1
• NCBI Protein Information: vasopressin V1a receptor; AVPR V1a; OTTMUSP00000022915; antidiuretic hormone receptor 1a; V1a arginine vasopressin receptor; vascular/hepatic-type arginine vasopressin receptor
• UniProt Protein Name: Arginine vasopressin receptor 1A
• Protein Family: Vasopressin V1a receptor
• UniProt Gene Name: Avpr1a
• UniProt Entry Name: Q3U1H9_MOUSE

NCBI Description

This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues [provided by RefSeq]

Uniprot Description

AVPR1A: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Cellular Component: membrane; integral to plasma membrane; integral to membrane; plasma membrane; cytoplasmic vesicle; cytosol

Molecular Function: G-protein coupled receptor activity; signal transducer activity; peptide hormone binding; V1A vasopressin receptor binding; peptide binding; vasopressin receptor activity

Biological Process: grooming behavior; response to inorganic substance; maternal behavior; positive regulation of cellular pH reduction; calcium-mediated signaling; positive regulation of glutamate secretion; positive regulation of heart rate; positive regulation of systemic arterial blood pressure; social behavior; signal transduction; positive regulation of cell growth; cellular response to hormone stimulus; response to organic substance; negative regulation of female receptivity; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; negative regulation of transmission of nerve impulse; regulation of systemic arterial blood pressure by vasopressin; positive regulation of cell proliferation; positive regulation of vasoconstriction; sperm ejaculation; positive regulation of blood pressure; positive regulation of prostaglandin biosynthetic process; penile erection