Rabbit anti-Mouse Vanilloid Receptor Like Protein 3 Polyclonal Antibody | anti-TRPV3 antibody

Vanilloid Receptor Like Protein 3 (Vanilloid Receptor-like 3, VRL 3, VRL-3, VRL3, HGNC:18084, Transient Receptor Potential Cation Channel Subfamily V Member 3, Trpv3 Heat Sensitive Channel, TRPV3)

Cat. Num. AAA619510

• Gene Names: TRPV3; VRL3; TRPV3
• Reactivity: Mouse
• Applications: ELISA, Western Blot
• Purity: Purified; Purified
• Synonyms: Vanilloid Receptor Like Protein 3; Polyclonal Antibody; Vanilloid Receptor Like Protein 3 (Vanilloid Receptor-like 3; VRL 3; VRL-3; VRL3; HGNC:18084; Transient Receptor Potential Cation Channel Subfamily V Member 3; Trpv3 Heat Sensitive Channel; TRPV3); Anti -Vanilloid Receptor Like Protein 3 (Vanilloid Receptor-like 3; anti-TRPV3 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Specificity: Recognizes mouse Vanilloid Receptor like Protein 3, 91kD.
• Purity/Purification: Purified; Purified
• Form/Format: Supplied as lyophilized powder from 0.01M PBS, pH 7.4. Reconstitute with 100ul of sterile 40-50% glycerol, ddH2O.

• Applicable Applications for anti-TRPV3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use ELISA and Western Blot.; Dilution: ELISA: 1:5000; Western Blot: 1:2000, detects the 91kD Vanilloid Receptor like Protein 3 in mouse brain tissue extract.
• Immunogen: Synthetic peptide (YRPREEEAI) corresponding to aa461-469 of mouse Vanilloid Receptor Like Protein3, (KLH).
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute by adding sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-TRPV3 antibody

Vanilloid Receptor-like 3 (VRL-3), also known as transient receptor potential cation channel subfamily V3 (TRPV3) is a 70 kD member of the vanilloid receptor/TRP gene family. It is expressed on keratinocytes and neurons, and is physiologically responsive to changes in temperature between 22 degree C and 40 degree C. Human TRPV3 is 790 amino acids (aa) in length. It is a 6 transmembrane domain protein that contains an N- and C-terminal cytoplasmic region. Three ankyrin repeats occur in the extended N-terminal cytoplasmic region (aa # 214-369). There is one alternate splice form that shows a 6 aa substituton for the C-terminal 31 amino acids. Over amino acids 6-15, human TRPV3 shares 90% aa sequence identity with mouse and canine TRPV3. TRPV3 is expressed in skin, tongue, dorsal root ganglion, trigeminal ganglion, spinal cord and brain and is thermosensitive in the physiological range of temperatures between TRPM8 and TRPV1.

Product Categories/Family for anti-TRPV3 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 22651775
• NCBI GeneID: 162514
• UniProt Accession #: Q2M3L1; Q8NET8; Q8TET8
• Molecular Weight: 90,593 Da
• NCBI Official Full Name: vanilloid receptor like 3 protein splice variant a
• NCBI Official Synonym Full Names: transient receptor potential cation channel, subfamily V, member 3
• NCBI Official Symbol: TRPV3
• NCBI Official Synonym Symbols: VRL3; TRPV3
• NCBI Protein Information: transient receptor potential cation channel subfamily V member 3; VRL-3; vanilloid receptor 3; vanilloid receptor-like 3; vanilloid receptor-related osmotically activated channel protein
• UniProt Protein Name: TRPV3 protein
• Protein Family: Transient receptor potential cation channel subfamily
• UniProt Gene Name: TRPV3
• UniProt Entry Name: Q2M3L1_HUMAN

NCBI Description

This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. [provided by RefSeq]

Uniprot Description

TRPV3: Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). May form a heteromeric channel with TRPV1. Interacts with TRPV1. Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion. Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: integral to membrane; plasma membrane; receptor complex

Molecular Function: calcium channel activity

Biological Process: negative regulation of hair cycle; response to heat; transmembrane transport

Disease: Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques; Palmoplantar Keratoderma, Nonepidermolytic, Focal 2