Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Polyclonal Antibody | anti-MYC antibody
Polyclonal Antibody to V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC)
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF-ASECI DPSVVFPYPL NDSSSPKSCT SSDSTAFSPS SDSLLSSESS PRASPEPLVLHEETPPTTSS DSEEEQEDEE EIDVVSVEKR QTPAKRSESG SSPSRGHSKP PHSPLVLKRCHVSTHQHNYA APPSTRKDYP AAKRAKLDSG RVLKQISNNR KCSSPRSSDT EENDKRRTHN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSIQADE HKLTSEKDLLRKRREQLKHK LEQLRNSGA
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Uniprot Description
Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.
Protein type: DNA-binding; Nucleolus; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 15 D1|15 26.19 cM
Cellular Component: axon; cytoplasm; nuclear body; nuclear chromatin; nuclear euchromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein complex; spindle
Molecular Function: activating transcription factor binding; DNA binding; DNA binding transcription factor activity; double-stranded DNA binding; protein binding; protein complex binding; protein dimerization activity; protein heterodimerization activity; sequence-specific DNA binding; transcription factor binding; ubiquitin protein ligase binding
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; amino acid transport; B cell apoptosis; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in positive regulation of apoptotic process; canonical Wnt signaling pathway involved in positive regulation of wound healing; cell cycle arrest; cell proliferation; cellular iron ion homeostasis; cellular response to DNA damage stimulus; cellular response to hypoxia; chromatin remodeling; chromosome organization and biogenesis; detection of mechanical stimulus involved in sensory perception of sound; DNA damage response, signal transduction resulting in induction of apoptosis; DNA-templated transcription, initiation; ERK1 and ERK2 cascade; glucose metabolic process; inner mitochondrial membrane organization; lactic acid secretion; MAPK cascade; middle ear morphogenesis; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of gene expression; negative regulation of glucose import; negative regulation of monocyte differentiation; negative regulation of protein binding; negative regulation of transcription from RNA polymerase II promoter; pigmentation; positive regulation of apoptotic signaling pathway; positive regulation of ATP biosynthetic process; positive regulation of B cell apoptotic process; positive regulation of catalytic activity; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA binding; positive regulation of DNA biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of glycolysis; positive regulation of mesenchymal cell proliferation; positive regulation of metanephric cap mesenchymal cell proliferation; positive regulation of mitochondrial membrane potential; positive regulation of oxidative phosphorylation; positive regulation of response to DNA damage stimulus; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of telomerase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein processing; protein-DNA complex disassembly; pyruvate transport; re-entry into mitotic cell cycle; regulation of apoptosis; regulation of gene expression; regulation of mitotic cell cycle; regulation of oxidative phosphorylation; regulation of telomere maintenance; regulation of transcription, DNA-templated; response to alkaloid; response to gamma radiation; response to radiation; skeletal morphogenesis; transcription from RNA polymerase II promoter; transcription, DNA-dependent; transformation of host cell by virus; Wnt receptor signaling pathway through beta-catenin; Wnt signaling pathway
Research Articles on MYC
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Product Notes
The MYC myc (Catalog #AAA2007212) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the MYC myc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF -ASECI DPSVVFPYPL NDSSSPKSCT SSDSTAFSPS SDSLLSSESS PRASPEPLVL HEETPPTTSS DSEEEQEDEE EIDVVSVEKR QTPAKRSESG SSPSRGHSKP PHSPLVLKRC HVSTHQHNYA APPSTRKDYP AAKRAKLDSG RVLKQISNNR KCSSPRSSDT EENDKRRTHN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSIQADE HKLTSEKDLL RKRREQLKHK LEQLRNSGA. It is sometimes possible for the material contained within the vial of "V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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