Rabbit Unrip Polyclonal Antibody | anti-STRAP antibody

Unrip Antibody

Cat. Num. AAA9629149

• Gene Names: STRAP; MAWD; PT-WD; UNRIP
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: Unrip; Polyclonal Antibody; Unrip Antibody; MAP activator with WD repeats; MAWD; PTWD; Serine-threonine kinase receptor-associated protein; serine/threonine kinase receptor associated protein; strap; STRAP_HUMAN; UNR-interacting protein; UNRIP; WD 40 repeat protein PT WD; WD-40 repeat protein PT-WD; anti-STRAP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Unrip Antibody detects endogenous levels of total Unrip.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-STRAP antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: Belongs to the WD repeat STRAP family.
• Subunit Structure: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with GEMIN6 and GEMIN7. Associates with the SMN complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Interacts with PRMT5; facilitates the interaction between PRMT5 and TP53.
• Function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
• Note: Localized predominantly in the cytoplasm but also found in the nucleus.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-STRAP antibody

Cytoplasm; Nucleus; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 148727341
• NCBI GeneID: 11171
• NCBI Accession #: NP_009109.3
• NCBI GenBank Nucleotide #: NM_007178.3
• UniProt Accession #: Q9Y3F4; Q5TZT4; Q9NTK0; Q9UQC8; B2R5S5; B4DNJ6
• Molecular Weight: 39,778 Da
• NCBI Official Full Name: serine-threonine kinase receptor-associated protein
• NCBI Official Synonym Full Names: serine/threonine kinase receptor associated protein
• NCBI Official Symbol: STRAP
• NCBI Official Synonym Symbols: MAWD; PT-WD; UNRIP
• NCBI Protein Information: serine-threonine kinase receptor-associated protein
• UniProt Protein Name: Serine-threonine kinase receptor-associated protein
• Protein Family: Serine-threonine kinase receptor-associated protein
• UniProt Gene Name: STRAP
• UniProt Synonym Gene Names: MAWD; UNRIP
• UniProt Entry Name: STRAP_HUMAN

Uniprot Description

STRAP: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associates with the complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Belongs to the WD repeat STRAP family.

Protein type: Adaptor/scaffold; RNA splicing

Chromosomal Location of Human Ortholog: 12p12.3

Cellular Component: cytoplasm; cytosol; nucleus; SMN complex

Molecular Function: protein binding; receptor binding

Biological Process: maintenance of gastrointestinal epithelium; negative regulation of epithelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; spliceosomal snRNP biogenesis