Serine-threonine kinase receptor-associated protein (STRAP) Recombinant Protein | STRAP recombinant protein

Recombinant Human Serine-threonine kinase receptor-associated protein (STRAP)

Cat. Num. AAA1337882

• Gene Names: STRAP; MAWD; PT-WD; UNRIP
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Serine-threonine kinase receptor-associated protein (STRAP); Recombinant Human Serine-threonine kinase receptor-associated protein (STRAP); Serine-threonine kinase receptor-associated protein; MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD; STRAP recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-350aa; Full Length
• Sequence: MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA
• Sequence Length: 350

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-PAGE

Related Product Information for STRAP recombinant protein

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.

NCBI and Uniprot Product Information

• NCBI GI #: 148727341
• NCBI GeneID: 11171
• NCBI Accession #: NP_009109.3
• NCBI GenBank Nucleotide #: NM_007178.3
• UniProt Accession #: Q9Y3F4; Q5TZT4; Q9NTK0; Q9UQC8; B2R5S5
• Molecular Weight: 65.4 kDa
• NCBI Official Full Name: serine-threonine kinase receptor-associated protein
• NCBI Official Synonym Full Names: serine/threonine kinase receptor associated protein
• NCBI Official Symbol: STRAP
• NCBI Official Synonym Symbols: MAWD; PT-WD; UNRIP
• NCBI Protein Information: serine-threonine kinase receptor-associated protein; unr-interacting protein; WD-40 repeat protein PT-WD; MAP activator with WD repeats
• UniProt Protein Name: Serine-threonine kinase receptor-associated protein
• Protein Family: Serine-threonine kinase receptor-associated protein
• UniProt Gene Name: STRAP
• UniProt Synonym Gene Names: MAWD; UNRIP
• UniProt Entry Name: STRAP_HUMAN

Uniprot Description

STRAP: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associates with the complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Belongs to the WD repeat STRAP family.

Protein type: Adaptor/scaffold; RNA splicing

Chromosomal Location of Human Ortholog: 12p12.3

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; SMN complex; nucleus; cytosol

Molecular Function: protein binding; receptor binding

Biological Process: spliceosomal snRNP biogenesis; maintenance of gastrointestinal epithelium; transforming growth factor beta receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of epithelial cell proliferation