Goat Unc5b Polyclonal Antibody | anti-Unc5b antibody
Goat anti-Unc5b (mouse, rat) Antibody
Gene Names
Unc5b; Unc5h2; A630020F16; D10Bwg0792e; 6330415E02Rik
Reactivity
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Applications
ELISA
Purity
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Synonyms
Unc5b; Polyclonal Antibody; Goat anti-Unc5b (mouse; rat) Antibody; Goat Anti-UNC5B Antibody; unc-5 homolog B (C. elegans); 6330415E02Rik; A630020F16; D10Bwg0792e; Unc5h2; netrin receptor UNC5B; protein unc-5 homolog 2; protein unc-5 homolog B; unc-5 homolog 2; unc5 homolog 2; 6330415E02Rik antibody; A630020F16 antibody; D10Bwg0792e antibody; netrin receptor UNC5B antibody; protein unc-5 homolog 2 antibody; protein unc-5 homolog B antibody; unc5 homolog 2 antibody; unc-5 homolog 2 antibody; unc-5 homolog B (C. elegans) antibody; Unc5b antibody; Unc5h2 antibody; Unc5b (mouse; rat); anti-Unc5b antibody
Host
Goat
Reactivity
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Clonality
Polyclonal
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (varies by lot)
Sequence
DWIFQLKTQAHQGH
Sequence Length
945
Applicable Applications for anti-Unc5b antibody
Peptide ELISA (EIA)
Application Notes
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Preliminary experiments in Human and rodent Brain, Lung and Spleen lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
Western Blot: Preliminary experiments in Human and rodent Brain, Lung and Spleen lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
Immunogen
Peptide with sequence C-DWIFQLKTQAHQGH, from the internal region of the protein sequence according to NP_084046.2.
Epitope
Internal region
Note
This antibody is expected to recognize the cytoplasmic domain of the protein.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
102,452 Da
NCBI Official Full Name
netrin receptor UNC5B
NCBI Official Synonym Full Names
unc-5 netrin receptor B
NCBI Official Symbol
Unc5b
NCBI Official Synonym Symbols
Unc5h2; A630020F16; D10Bwg0792e; 6330415E02Rik
NCBI Protein Information
netrin receptor UNC5B
UniProt Protein Name
Netrin receptor UNC5B
Protein Family
UniProt Gene Name
Unc5b
UniProt Synonym Gene Names
Unc5h2
UniProt Entry Name
UNC5B_MOUSE
Uniprot Description
UNC5B: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. Belongs to the unc-5 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: integral to membrane; lipid raft; membrane; plasma membrane
Molecular Function: netrin receptor activity; protein binding
Biological Process: angiogenesis; anterior/posterior axon guidance; apoptosis; axon guidance; multicellular organismal development; negative regulation of neuron apoptosis; positive regulation of phosphoinositide 3-kinase cascade; signal transduction
Research Articles on Unc5b
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Product Notes
The Unc5b unc5b (Catalog #AAA423084) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-Unc5b (mouse, rat) Antibody reacts with Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's Unc5b can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Preliminary experiments in Human and rodent Brain, Lung and Spleen lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). Researchers should empirically determine the suitability of the Unc5b unc5b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: DWIFQLKTQA HQGH. It is sometimes possible for the material contained within the vial of "Unc5b, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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