Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Rat Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Polyclonal Antibody | anti-TNFRSF1A antibody
Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A)
MGHHHHHHSGSEF- VEGE GIVTKPLTPA SIPAFSPNPG FNPTLGFSTT PRFSHPVSST PISPVFGPSN WHNFVPPVRE VVPTQGADPL LYGSLNPVPI PAPVRKWEDV VAAQPQRLDT ADPAMLYAVV DGVPPTRWKE FMRLLGLSEH EIERLELQNG RCLREAHYSM LEAWRRRTPR HEATLDVVGR VLCDMNLRGC LENIRETLES PAHSSTTH
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
NCBI and Uniprot Product Information
NCBI Description
may play a role in TNFalpha mediated inflammatory response to spinal cord injury [RGD, Feb 2006]
Uniprot Description
TNF-R1: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 4q42
Cellular Component: axon; cell surface; cytosol; extracellular space; Golgi membrane; integral component of membrane; integral component of plasma membrane; membrane raft; mitochondrion; nucleus; protein complex; receptor complex; synapse
Molecular Function: identical protein binding; protease binding; protein binding; protein complex binding; tumor necrosis factor binding; tumor necrosis factor-activated receptor activity
Biological Process: cell surface receptor signaling pathway; cytokine-mediated signaling pathway; defense response; defense response to bacterium; DNA damage response, signal transduction resulting in induction of apoptosis; immune response; inflammatory response; negative regulation of apoptosis; negative regulation of inflammatory response; negative regulation of interleukin-6 production; positive regulation of angiogenesis; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of inflammatory response; positive regulation of neuron apoptotic process; positive regulation of protein import into nucleus, translocation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of STAT protein; prostaglandin metabolic process; protein heterooligomerization; regulation of apoptosis; regulation of cell proliferation; response to alkaloid; response to amino acid; response to ethanol; response to hypoxia; response to lipopolysaccharide; response to wounding; tetrapyrrole metabolic process; tumor necrosis factor-mediated signaling pathway
Research Articles on TNFRSF1A
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Product Notes
The TNFRSF1A tnfrsf1a (Catalog #AAA2006774) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the TNFRSF1A tnfrsf1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF- VEGE GIVTKPLTPA SIPAFSPNPG FNPTLGFSTT PRFSHPVSST PISPVFGPSN WHNFVPPVRE VVPTQGADPL LYGSLNPVPI PAPVRKWEDV VAAQPQRLDT ADPAMLYAVV DGVPPTRWKE FMRLLGLSEH EIERLELQNG RCLREAHYSM LEAWRRRTPR HEATLDVVGR VLCDMNLRGC LENIRETLES PAHSSTTH. It is sometimes possible for the material contained within the vial of "Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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