Western Blot (WB)
(Western Blot: Sample: Lane1: Human HepG2 Cells; Lane2: Human Hela Cells.)
Rabbit anti-Mouse Tumor Necrosis Factor Alpha Induced Protein 3 Interacting Protein 2 (TNIP2) Polyclonal Antibody | anti-TNIP2 antibody
Polyclonal Antibody to Tumor Necrosis Factor Alpha Induced Protein 3 Interacting Protein 2 (TNIP2)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- A KCLDERQCAQ GDAGEKSPAE LEQTSSDASG QSVIKKLQEE NRLLKQKVTH VEDLNAKWQR YDASRDEYVK GLHAQLKRRQ VPLEPELMKK EISRLNRQLE EKISDCAEAN QELTAMRMSR DTALERVQML EQQILAYKDD FKSERADRER AHSRIQELEE KIMSLMYQVS QRQDSREPGP CRIHTGNKTA KYLEMDALEH VTPGGWRPES RSQQMEPSAE GGHVCTAQRG QGDLQCPHCL RCF
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Lane1: Human HepG2 Cells; Lane2: Human Hela Cells.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Human HepG2 Cells; Lane2: Human Hela Cells.)
Western Blot (WB)
(Western Blot: Sample: Recombinant TNIP2, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant TNIP2, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Brain Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Brain Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Testis Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Testis Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Liver Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Liver Tissue.)
NCBI and Uniprot Product Information
Uniprot Description
TNIP2: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 5|5 B2
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: metal ion binding; polyubiquitin modification-dependent protein binding; protein binding; protein kinase binding
Biological Process: apoptosis; I-kappaB kinase/NF-kappaB signaling; inflammatory response; positive regulation of B cell activation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of macrophage activation; positive regulation of transcription from RNA polymerase II promoter; protein stabilization; regulation of transcription, DNA-templated; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 9 signaling pathway; transcription, DNA-dependent
Research Articles on TNIP2
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Product Notes
The TNIP2 tnip2 (Catalog #AAA2006911) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Tumor Necrosis Factor Alpha Induced Protein 3 Interacting Protein 2 (TNIP2) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Tumor Necrosis Factor Alpha Induced Protein 3 Interacting Protein 2 (TNIP2) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the TNIP2 tnip2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- A KCLDERQCAQ GDAGEKSPAE LEQTSSDASG QSVIKKLQEE NRLLKQKVTH VEDLNAKWQR YDASRDEYVK GLHAQLKRRQ VPLEPELMKK EISRLNRQLE EKISDCAEAN QELTAMRMSR DTALERVQML EQQILAYKDD FKSERADRER AHSRIQELEE KIMSLMYQVS QRQDSREPGP CRIHTGNKTA KYLEMDALEH VTPGGWRPES RSQQMEPSAE GGHVCTAQRG QGDLQCPHCL RCF. It is sometimes possible for the material contained within the vial of "Tumor Necrosis Factor Alpha Induced Protein 3 Interacting Protein 2 (TNIP2), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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