Western Blot (WB)
(TULP1 Antibody (Center) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the TULP1 antibody detected the TULP1 protein (arrow).)
Rabbit anti-Human TULP1 Polyclonal Antibody | anti-TULP1 antibody
TULP1 Antibody (Center)
Western Blot (WB)
(TULP1 Antibody (Center) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the TULP1 antibody detected the TULP1 protein (arrow).)
Western Blot (WB)
(TULP1 Antibody (Center) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the TULP1 antibody detected the TULP1 protein (arrow).)
(TULPs). Members of this family have been identified in plants,
vertebrates, and invertebrates and encode proteins of unknown
function. TULP proteins share a conserved C-terminal region of
approximately 200 amino acid residues. Mutations in this gene may
be associated with retinitis pigmentosa.
Caberoy, N.B., et al. Exp. Cell Res. 316(2):245-257(2010)
Abbasi, A.H., et al. Mol. Vis. 14, 675-682 (2008) :
Mataftsi, A., et al. Invest. Ophthalmol. Vis. Sci. 48(11):5160-5167(2007)
den Hollander, A.I., et al. Arch. Ophthalmol. 125(7):932-935(2007)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the tubby-like gene family (TULPs). Members of this family have been identified in plants, vertebrates, and invertebrates and encode proteins of unknown function. TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. Mutations in this gene may be associated with juvenile retinitis pigmentosa and Leber congenital amaurosis-15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Description
TULP1: Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells. Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. Defects in TULP1 are the cause of retinitis pigmentosa type 14 (RP14). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP14 inheritance is autosomal recessive. Defects in TULP1 are the cause of Leber congenital amaurosis type 15 (LCA15). LCA15 is a severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. Belongs to the TUB family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: cell projection; photoreceptor outer segment; photoreceptor inner segment; cytoplasm; plasma membrane; extracellular region; synapse; cell junction
Molecular Function: actin filament binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; G-protein coupled photoreceptor activity
Biological Process: retinal homeostasis; eye photoreceptor cell development; visual perception; retina development in camera-type eye; positive regulation of phagocytosis; photoreceptor cell maintenance; dendrite development; phototransduction; detection of light stimulus involved in visual perception; phagocytosis
Disease: Retinitis Pigmentosa 14; Leber Congenital Amaurosis 15
Research Articles on TULP1
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Product Notes
The TULP1 tulp1 (Catalog #AAA9206646) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 184-211. The TULP1 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TULP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the TULP1 tulp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TULP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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