Goat anti-Human TTR / Transthyretin Polyclonal Antibody | anti-TTR antibody

Goat Polyclonal (IgG) to Human TTR / Transthyretin

Cat. Num. AAA248027

• Gene Names: TTR; CTS; CTS1; PALB; TBPA; HEL111; HsT2651
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: TTR / Transthyretin; Polyclonal Antibody; Goat Polyclonal (IgG) to Human TTR / Transthyretin; Anti-TTR / Transthyretin Antibody IHC-plus; TTR; ATTR; CTS1; CTS; HsT2651; PALB; Prealbumin; TBPA; Transthyretin; Carpal tunnel syndrome 1; amyloidosis type I; Thyroxine-binding prealbumin; Human TTR; anti-TTR antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Prealbumin.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, pH 7.2, 0.05% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 147

• Applicable Applications for anti-TTR antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA, IHC-P (2.5 ug/ml)
• Target Species: Human
• Immunogen Description: Human Prealbumin.
• Immunogen: TTR / Transthyretin antibody was raised against human Prealbumin.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months.

Immunohistochemistry (IHC)

(Anti-TTR / Transthyretin antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-TTR antibody

Prealbumin, also known as transethrytin (TTR) is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic.

NCBI and Uniprot Product Information

• NCBI GI #: 4507725
• NCBI GeneID: 7276
• NCBI Accession #: NP_000362.1
• NCBI GenBank Nucleotide #: NM_000371.3
• UniProt Accession #: P02766; Q549C7; Q6IB96; Q9UBZ6; Q9UCM9
• Molecular Weight: 15,887 Da
• NCBI Official Full Name: transthyretin
• NCBI Official Synonym Full Names: transthyretin
• NCBI Official Symbol: TTR
• NCBI Official Synonym Symbols: CTS; CTS1; PALB; TBPA; HEL111; HsT2651
• NCBI Protein Information: transthyretin; ATTR; carpal tunnel syndrome 1; thyroxine-binding prealbumin; epididymis luminal protein 111; prealbumin, amyloidosis type I
• UniProt Protein Name: Transthyretin
• Protein Family: Transthyretin
• UniProt Gene Name: TTR
• UniProt Synonym Gene Names: PALB
• UniProt Entry Name: TTHY_HUMAN

NCBI Description

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]

Uniprot Description

TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: extracellular space; protein complex; cytoplasm; extracellular region

Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; hormone activity

Biological Process: phototransduction, visible light; extracellular matrix organization and biogenesis; transport; retinol metabolic process; retinoid metabolic process

Disease: Hyperthyroxinemia, Dystransthyretinemic; Carpal Tunnel Syndrome; Amyloidosis, Hereditary, Transthyretin-related