Rabbit anti-Human, Mouse TTBK2 Polyclonal Antibody | anti-TTBK2 antibody

TTBK2 Antibody

Cat. Num. AAA9604202

• Gene Names: TTBK2; TTBK; SCA11
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: TTBK2; Polyclonal Antibody; TTBK2 Antibody; KIAA0847; mKIAA0847; SCA11; Spinocerebellar ataxia 11; Tau tubulin kinase 2; Tau-tubulin kinase 2; TTBK; TTBK 2; TTBK1; TTBK2_HUMAN; TTK; anti-TTBK2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TTBK2 antibody detects endogenous levels of total TTBK2
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 1244

• Applicable Applications for anti-TTBK2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide
• Subcellular Location: Cytoskeleton; Cytosol; Nucleus
• Conjugation: Unconjugated

Western Blot (WB)

(Western blot analysis of TTBK2 expression in Mouse thymus lysate ;, The lane on the left is treated with the antigen-specific peptide.)

Related Product Information for anti-TTBK2 antibody

Function: Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.
Subunit Structure: Interacts with CEP164.
Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.

NCBI and Uniprot Product Information

• NCBI GI #: 116812624
• NCBI GeneID: 146057
• NCBI Accession #: NP_775771.3
• NCBI GenBank Nucleotide #: NM_173500.3
• UniProt Accession #: Q6IQ55; O94932; Q6ZN52; Q8IVV1
• Molecular Weight: Observed: 137 kDa; Predicted: 138 kDa
• NCBI Official Full Name: tau-tubulin kinase 2
• NCBI Official Synonym Full Names: tau tubulin kinase 2
• NCBI Official Symbol: TTBK2
• NCBI Official Synonym Symbols: TTBK; SCA11
• NCBI Protein Information: tau-tubulin kinase 2
• UniProt Protein Name: Tau-tubulin kinase 2
• Protein Family: Tau-tubulin kinase
• UniProt Gene Name: TTBK2
• UniProt Synonym Gene Names: KIAA0847

NCBI Description

This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]

Uniprot Description

Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.