Human Calcium activated chloride channel regulator 2 (CLCA2) ELISA Kit | CLCA2 elisa kit
Human Calcium activated chloride channel regulator 2 (CLCA2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. [provided by RefSeq, Jul 2008]
Uniprot Description
CLCA5: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. Belongs to the CLCR family.
Protein type: Membrane protein, integral; Channel, chloride
Chromosomal Location of Human Ortholog: 1p22.3
Cellular Component: integral to plasma membrane; plasma membrane; basal plasma membrane; extracellular region; cell junction
Molecular Function: chloride channel activity; metallopeptidase activity; metal ion binding; ligand-gated ion channel activity
Biological Process: transport; proteolysis; cell adhesion; transmembrane transport
Research Articles on CLCA2
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Product Notes
The Human CLCA2 clca2 (Catalog #AAA7242681) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7242681 ELISA Kit recognizes Human CLCA2. It is sometimes possible for the material contained within the vial of "Calcium activated chloride channel regulator 2 (CLCA2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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