Rabbit anti-Mouse TSPYL5 Polyclonal Antibody | anti-TSPYL5 antibody

TSPYL5, CT (TSPYL5, KIAA1750, Testis-specific Y-encoded-like protein 5)

Cat. Num. AAA6001735

• Reactivity: Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: TSPYL5; Polyclonal Antibody; CT (TSPYL5; KIAA1750; Testis-specific Y-encoded-like protein 5); Anti -TSPYL5; anti-TSPYL5 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-TSPYL5 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot, Immunohistochemistry, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500; Immunohistochemistry: 1:10-50
• Immunogen: TSPYL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-372 amino acids from the C-terminal region of human TSPYL5.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in mouse cerebellum tissue lysates (35ug/lane) using MBS6001735. This demonstrates MBS6001735 detected the TSPYL5 protein (arrow).)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue using MBS6001735 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS6001735 for immunohistochemistry.)

Related Product Information for anti-TSPYL5 antibody

The function of this protein remains unknown.

Product Categories/Family for anti-TSPYL5 antibody

Antibodies; Abs to KIAA; orf

NCBI and Uniprot Product Information

• NCBI GI #: 49410495
• NCBI GeneID: 85453
• NCBI Accession #: NP_277047.2
• NCBI GenBank Nucleotide #: NM_033512.2
• UniProt Accession #: Q86VY4; Q9C0B3; B3KRF0
• Molecular Weight: 45,143 Da
• NCBI Official Full Name: testis-specific Y-encoded-like protein 5
• NCBI Official Synonym Full Names: TSPY-like 5
• NCBI Official Symbol: TSPYL5
• NCBI Protein Information: testis-specific Y-encoded-like protein 5; TSPY-like protein 5
• UniProt Protein Name: Testis-specific Y-encoded-like protein 5
• Protein Family: Testis-specific Y-encoded-like protein
• UniProt Gene Name: TSPYL5
• UniProt Synonym Gene Names: KIAA1750; TSPY-like protein 5
• UniProt Entry Name: TSYL5_HUMAN

Uniprot Description

TSPYL5: Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. Belongs to the nucleosome assembly protein (NAP) family.

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: nucleus

Molecular Function: protein binding

Biological Process: positive regulation of protein kinase B signaling cascade; nucleosome assembly; positive regulation of protein ubiquitination; regulation of growth; positive regulation of cell proliferation