Rabbit anti-Human, Mouse TSHZ1 Polyclonal Antibody | anti-TSHZ1 antibody

TSHZ1 Polyclonal Antibody

Cat. Num. AAA3007203

• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TSHZ1; Polyclonal Antibody; TSHZ1 Polyclonal Antibody; Teashirt homolog 1; Antigen NY-CO-33; Serologically defined colon cancer antigen 33; SDCCAG33; TSH1; anti-TSHZ1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TSHZ1 polyclonal antibody detects endogenous levels of TSHZ1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1032

• Applicable Applications for anti-TSHZ1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human TSHZ1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of TSHZ1 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysateLane2:RAW264. 7 whole cell lysate)

Related Product Information for anti-TSHZ1 antibody

The Teashirt zinc finger homeobox (TSHZ) family comprise a family of evolutionarily conserved transcription factors that, in Drosophila, are active in specific body parts for patterning, but whose function in vertebrates is less clear. TSHZ1 has been found to be required for axial skeleton, soft palate and middle ear development in mice and may be involved in a common pathway with the Hox genes. Both TSHZ1 and the related protein TSHZ3 have been found to interact with FE65, an adapter protein that binds to the amyloid protein precursor (APP) in neurons. Together with SET, a component of the inhibitor of acetyl transferase, and histone deacetylases, these proteins formed a gene-silencing complex whose target includes caspase-4.

NCBI and Uniprot Product Information

• NCBI GI #: 38201677
• NCBI Accession #: NP_005777
• NCBI GenBank Nucleotide #: NP_005777.3
• UniProt Accession #: Q6ZSZ6
• Molecular Weight: ~ 113kDa
• NCBI Official Full Name: teashirt homolog 1 isoform 2
• UniProt Protein Name: Teashirt homolog 1
• Protein Family: Teashirt
• UniProt Gene Name: TSHZ1
• UniProt Synonym Gene Names: SDCCAG33; TSH1
• UniProt Entry Name: TSH1_HUMAN

Uniprot Description

TSHZ1: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Defects in TSHZ1 are the cause of congenital aural atresia (CAA). A rare anomaly of the ear that involves some degree of failure of the development of the external auditory canal. The malformation can also involve the tympanic membrane, ossicles and middle ear space. The inner ear development is most often normal. Different CAA forms are known. CAA type I is characterized by bony or fibrous atresia of the lateral part of the external auditory canal and an almost normal medial part and middle ear. CAA type II is the most frequent type and is characterized by partial or total aplasia of the external auditory canal. CAA type IIA involves an external auditory canal with either complete bony atresia of the medial part or partial aplasia that ends blindly in a fistula leading to a rudimentary tympanic membrane. CAA type IIB is characterized by bony stenosis of the total length of the external auditory canal. CAA type III involves bony atresia of the external auditory canal and a very small or absent middle-ear cavity. Belongs to the teashirt C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 18q22.3

Cellular Component: nucleus

Molecular Function: DNA binding; metal ion binding

Biological Process: anterior/posterior pattern formation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; middle ear morphogenesis; soft palate development

Disease: Aural Atresia, Congenital