Western Blot (WB)
(Western blot analysis of TSHZ1 in A-20 cell lysate with TSHZ1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)
TSHZ1 blocking peptide
TSHZ1 Peptide
Western Blot (WB)
(Western blot analysis of TSHZ1 in A-20 cell lysate with TSHZ1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)
Western Blot (WB)
(Western blot analysis of TSHZ1 in A-20 cell lysate with TSHZ1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome. [provided by RefSeq, Jan 2012]
Uniprot Description
TSHZ1: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Defects in TSHZ1 are the cause of congenital aural atresia (CAA). A rare anomaly of the ear that involves some degree of failure of the development of the external auditory canal. The malformation can also involve the tympanic membrane, ossicles and middle ear space. The inner ear development is most often normal. Different CAA forms are known. CAA type I is characterized by bony or fibrous atresia of the lateral part of the external auditory canal and an almost normal medial part and middle ear. CAA type II is the most frequent type and is characterized by partial or total aplasia of the external auditory canal. CAA type IIA involves an external auditory canal with either complete bony atresia of the medial part or partial aplasia that ends blindly in a fistula leading to a rudimentary tympanic membrane. CAA type IIB is characterized by bony stenosis of the total length of the external auditory canal. CAA type III involves bony atresia of the external auditory canal and a very small or absent middle-ear cavity. Belongs to the teashirt C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 18q22.3
Cellular Component: nucleus
Molecular Function: DNA binding; metal ion binding
Biological Process: anterior/posterior pattern formation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; soft palate development; middle ear morphogenesis
Disease: Aural Atresia, Congenital
Research Articles on TSHZ1
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Product Notes
The TSHZ1 tshz1 (Catalog #AAA151795) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TSHZ1 can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). TSHZ1 peptide is used for blocking the activity of TSHZ1 antibody. Researchers should empirically determine the suitability of the TSHZ1 tshz1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TSHZ1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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