Rabbit anti-Human TSC-22R Polyclonal Antibody | anti-TSC-22R antibody

TSC-22R Antibody

Cat. Num. AAA9602936

• Gene Names: TSC22D3; DIP; GILZ; DSIPI; TSC-22R
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: TSC-22R; Polyclonal Antibody; TSC-22R Antibody; Delta sleep-inducing peptide immunoreactor; DIP; DSIP immunoreactive leucine zipper protein; DSIP-immunoreactive peptide; Dsip1; Dsipi; GILZ; Glucocorticoid-induced leucine zipper protein; hDIP; Protein DIP; T22D3_HUMAN; TSC-22-like protein; TSC-22-related protein; TSC22 domain family protein 3; TSC22 domain family; member 3; TSC22 related inducible leucine zipper 3; TSC22D3; anti-TSC-22R antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TSC-22R antibody detects endogenous levels of total TSC-22R
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 77

• Applicable Applications for anti-TSC-22R antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:1000-3000
• Immunogen: A synthesized peptide derived from human TSC-22R
• Subcellular Location: Nucleus
• Tissue Specificity: Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B-and T-cells, monocytes and granulocytes. Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of TSC-22R using HepG2 whole cell lysates)

Related Product Information for anti-TSC-22R antibody

Function: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).
Subunit Structure: Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 (By similarity). Interacts with NFKB1. Isoform 1 interacts with MYOD1 (By similarity). Isoform 1 interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity (By similarity).
Similarity: The leucine-zipper is involved in homodimerization. Belongs to the TSC-22/Dip/Bun family.

NCBI and Uniprot Product Information

• NCBI GI #: 62865625
• NCBI GeneID: 1831
• NCBI Accession #: NP_001015881.1
• NCBI GenBank Nucleotide #: NM_001015881.1
• UniProt Accession #: Q99576; Q5H9S3; Q5JRI9; Q6FIH6; Q8NAI1; Q8WVB9; Q9UBN5; Q9UG13
• Molecular Weight: Observed: 15 kDa; Predicted: 15 kDa
• NCBI Official Full Name: TSC22 domain family protein 3 isoform 3
• NCBI Official Synonym Full Names: TSC22 domain family member 3
• NCBI Official Symbol: TSC22D3
• NCBI Official Synonym Symbols: DIP; GILZ; DSIPI; TSC-22R
• NCBI Protein Information: TSC22 domain family protein 3
• UniProt Protein Name: TSC22 domain family protein 3
• UniProt Gene Name: TSC22D3
• UniProt Synonym Gene Names: DSIPI; GILZ; Protein DIP; hDIP; GILZ; TSC-22R

NCBI Description

This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Description

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG ().