Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using TRPC4 antibody.)
Rabbit anti-Human, Mouse TRPC4 Polyclonal Antibody | anti-TRPC4 antibody
TRPC4 Polyclonal Antibody
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using TRPC4 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using TRPC4 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
TRPC4: Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, calcium; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q13.3
Cellular Component: cortical cytoskeleton; cell surface; basolateral plasma membrane; plasma membrane; intercellular junction; caveola
Molecular Function: store-operated calcium channel activity; protein binding; cadherin binding; beta-catenin binding
Biological Process: axon guidance; calcium ion transport; gamma-aminobutyric acid secretion; oligodendrocyte differentiation; transmembrane transport
Research Articles on TRPC4
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Product Notes
The TRPC4 trpc4 (Catalog #AAA9433917) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TRPC4 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TRPC4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the TRPC4 trpc4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRPC4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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