Rabbit TROP2 / TACSTD2 Polyclonal Antibody | anti-TROP2 antibody

Rabbit Polyclonal (IgG) to Human TROP2 / TACSTD2

Cat. Num. AAA248647

• Gene Names: TACSTD2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: TROP2 / TACSTD2; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human TROP2 / TACSTD2; Anti-TROP2 / TACSTD2 Antibody (aa131-180) IHC-plus; TACSTD2; EGP-1; EGP1; GA7331; M1S1; TROP2; Epithelial glycoprotein-1; GA733-1; gp50; Human TROP2; anti-TROP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TACD2 Antibody detects endogenous levels of total TACD2 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 323

• Applicable Applications for anti-TROP2 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:5000), IHC-P (5 ug/ml), WB (1:500 - 1:1000)
• Target Species: Human
• Immunogen Description: Synthetic peptide from human TACD2 (aa131-180).
• Immunogen: TROP2 / TACSTD2 antibody was raised against synthetic peptide from human TACD2 (aa131-180).
• Antigen Modification: aa131-180
• Preparation and Storage: Store at -20 degree C for up to one year.

Immunohistochemistry (IHC)

(Anti-TROP2 / TACSTD2 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of extracts from A549/NIH-3T3 cells, using TACD2 Antibody. The lane on the right is treated with the synthesized peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 166795236
• NCBI GeneID: 4070
• NCBI Accession #: NP_002344.2
• NCBI GenBank Nucleotide #: NM_002353.2
• UniProt Accession #: P09758; Q15658; Q6FG48; Q7Z7Q4; Q96QD2
• Molecular Weight: 35,709 Da
• NCBI Official Full Name: tumor-associated calcium signal transducer 2
• NCBI Official Synonym Full Names: tumor-associated calcium signal transducer 2
• NCBI Official Symbol: TACSTD2
• NCBI Official Synonym Symbols: EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
• NCBI Protein Information: tumor-associated calcium signal transducer 2; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733
• UniProt Protein Name: Tumor-associated calcium signal transducer 2
• UniProt Gene Name: TACSTD2
• UniProt Synonym Gene Names: GA733-1; M1S1; TROP2
• UniProt Entry Name: TACD2_HUMAN

NCBI Description

This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

Uniprot Description

TACSTD2: May function as a growth factor receptor. Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD); also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. Belongs to the EPCAM family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: extracellular space; membrane; integral to plasma membrane; basal plasma membrane; nucleus; cytosol; lateral plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: cell proliferation; cell surface receptor linked signal transduction; negative regulation of stress fiber formation; visual perception; regulation of epithelial cell proliferation

Disease: Corneal Dystrophy, Gelatinous Drop-like