Tumor-associated Calcium Signal Transducer 2/TROP-2 Active Protein | TROP-2 active protein

Recombinant Human Tumor-associated Calcium Signal Transducer 2/TROP-2 (248AA, C-Fc)

Cat. Num. AAA2569191

• Gene Names: TACSTD2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Tumor-associated Calcium Signal Transducer 2/TROP-2; Recombinant Human Tumor-associated Calcium Signal Transducer 2/TROP-2 (248AA; C-Fc); Tumor-associated calcium signal transducer 2; Membrane component chromosome 1 surface marker 1; Cell surface glycoprotein Trop-2; TACSTD2; TROP2; TROP-2 active protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: His27-Thr274

• Species: Human
• Tag: C-Fc
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Human Tumor-associated Calcium Signal Transducer 2 is produced by our Mammalian expression system and the target gene encoding His27-Thr274 is expressed with a Fc tag at the C-terminus.
• Activity: Immobilized Human TROP-2-Fc at 2ug/ml (100ul/well) can bind Anti-Human TROP-2 mAb*.*: Biotinylated by NHS-biotin prior to testing. The ED50 of Anti-Human TROP-2 mAb* is 20.54ng/ml.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Activity

Related Product Information for TROP-2 active protein

Tumor associated calcium signal transducer 2 (TACSTD2, TROP-2) is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family. Human and mouse TROP-2 share 87% amino acid (aa) similarity. TROP-2 is capable of transducing an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions.

NCBI and Uniprot Product Information

• NCBI GI #: 166795236
• NCBI GeneID: 4070
• NCBI Accession #: NP_002344.2
• NCBI GenBank Nucleotide #: NM_002353.2
• UniProt Accession #: P09758; Q15658; Q6FG48; Q7Z7Q4; Q96QD2
• Molecular Weight: 35,709 Da
• NCBI Official Full Name: tumor-associated calcium signal transducer 2
• NCBI Official Synonym Full Names: tumor-associated calcium signal transducer 2
• NCBI Official Symbol: TACSTD2
• NCBI Official Synonym Symbols: EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
• NCBI Protein Information: tumor-associated calcium signal transducer 2; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-ass
• UniProt Protein Name: Tumor-associated calcium signal transducer 2
• UniProt Gene Name: TACSTD2
• UniProt Synonym Gene Names: GA733-1; M1S1; TROP2
• UniProt Entry Name: TACD2_HUMAN

NCBI Description

This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

Uniprot Description

TACSTD2: May function as a growth factor receptor. Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD); also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. Belongs to the EPCAM family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: extracellular space; membrane; integral to plasma membrane; basal plasma membrane; nucleus; cytosol; lateral plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: cell proliferation; cell surface receptor linked signal transduction; negative regulation of stress fiber formation; visual perception; regulation of epithelial cell proliferation

Disease: Corneal Dystrophy, Gelatinous Drop-like