Western Blot (WB)
(Anti-TrkC antibody, MBS176236, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Mouse Brain Tissue LysateLane 3: U87 Cell Lysate )
Rabbit TrkC Polyclonal Antibody | anti-NTRK3 antibody
Anti-TrkC antibody
Western Blot (WB)
(Anti-TrkC antibody, MBS176236, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Mouse Brain Tissue LysateLane 3: U87 Cell Lysate )
Western Blot (WB)
(Anti-TrkC antibody, MBS176236, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Mouse Brain Tissue LysateLane 3: U87 Cell Lysate )
Background: NTRK3(Neurotrophic Tyrosine Kinase Receptor Type 3), also known as TRKC, is a protein that in humans is encoded by the NTRK3 gene. By PCR analysis of a somatic cell hybrid panel and by fluorescence in situ hybridization with the cDNA clone, McGregor et al.(1994) mapped the NTRK3 gene to 15q24-q25. Lamballe et al.(1991) isolated and characterized TRKC, a member of the TRK family of tyrosine protein kinase genes. They found that TRKC is preferentially expressed in the brain; in situ hybridization studies showed transcripts in the hippocampus, cerebral cortex, and the granular cell layer of the cerebellum. By functional studies in HeLa cells, Muinos-Gimeno et al.(2009) demonstrated that 5 miRNAs regulate the truncated form of NTRK3.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Uniprot Description
TrkC: a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known.
Protein type: Protein kinase, TK; Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 15q25
Cellular Component: integral to plasma membrane; cytoplasm; receptor complex
Molecular Function: neurotrophin binding; protein binding; ephrin receptor binding; p53 binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding
Biological Process: circadian rhythm; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; positive regulation of positive chemotaxis; activation of MAPK activity; protein amino acid autophosphorylation; activation of protein kinase B; positive regulation of axon extension involved in regeneration; neuron migration; positive regulation of peptidyl-serine phosphorylation; response to ethanol; negative regulation of protein amino acid phosphorylation; positive regulation of cell proliferation; negative regulation of astrocyte differentiation; modification by virus of host cell transcription; neuron fate specification; response to axon injury; transmembrane receptor protein tyrosine kinase signaling pathway; response to corticosterone stimulus; positive regulation of cell migration
Research Articles on NTRK3
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Product Notes
The NTRK3 ntrk3 (Catalog #AAA176236) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TrkC antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TrkC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the NTRK3 ntrk3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TrkC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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