Western Blot (WB)
(Western blot analysis of trkB expression in HL-60 cell lysate.)
Rabbit TrkB Polyclonal Antibody | anti-TrkB antibody
TrkB Antibody
Gene Names
NTRK2; OBHD; TRKB; trk-B; EIEE58; GP145-TrkB
Applications
Immunofluorescence, Immunoprecipitation, Western Blot
Purity
Affinity Chromatography
Synonyms
TrkB; Polyclonal Antibody; TrkB Antibody; Rabbit Polyclonal TrkB Antibody; Polyclonal TrkB antibody; anti-TrkB antibody; GP145-TrkB antibody; Trk-B antibody; TRKB antibody; NTRK2 antibody; tyrosine receptor kinase antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Chromatography
Form/Format
Supplied in PBS buffer containing 30% Glycerol, 0.5% BSA, and 0.01% Thimerosal
Concentration
200 ug/ml (varies by lot)
Sequence Length
822
Applicable Applications for anti-TrkB antibody
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)
Application Notes
IF: 5-10 ug/ml
WB: 0.5-4 ug/ml
WB: 0.5-4 ug/ml
Immunogen
TrkB antibody was raised in Rabbit using synthetic peptide surrounding amino acid 810 of human TrkB as the immunogen.
Cross-Reactivity
Human, Mouse, Rat, Chicken
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Western Blot (WB)
(Western blot analysis of trkB expression in HL-60 cell lysate.)
Western Blot (WB)
(Western blot analysis of trkB expression in HL-60 cell lysate.)
Related Product Information for anti-TrkB antibody
Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular weights of 140-145 kDa, 110 kDa and the unglycosylated form of 80 kDa. trkB contains 33.3% carbohydrate by weight representing modification on 10 of 12 N-glycosylation sites. The primary ligand for trkB is BDNF which induces the phosphorylation of the protein and subsequent binding of PLC-gamma via SH2 domains. TrkB may function to modulate neuronal responses to the neurotrophins acting through trkB such as BDNF.
Product Categories/Family for anti-TrkB antibody
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Research Articles on TrkB
1. coexpression of BDNF and TrkB is associated with poor prognosis in small cell lung cancer patients
Similar Products
Product Notes
The TrkB (Catalog #AAA5311382) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TrkB can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB). IF: 5-10 ug/ml WB: 0.5-4 ug/ml. Researchers should empirically determine the suitability of the TrkB for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TrkB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
