Immunohistochemistry (IHC)
(Immunochemical staining of human TRIM7 in human kidney with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human TRIM7 Polyclonal Antibody | anti-TRIM7 antibody
Anti-TRIM7 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
TRIM7; Polyclonal Antibody; Anti-TRIM7 Antibody; Rabbit Polyclonal; TRIM7 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-GNIP Antibody; anti-TRIM7 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human TRIM7
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-TRIM7 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:200-1:1000
Immunogen
E Coli-derived Human TRIM7 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human TRIM7 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human TRIM7 in human kidney with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human TRIM7 in human kidney with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-TRIM7 antibody
Members of the tripartite motif (TRIM) family as E3 ubiquitin ligases have been regarded as critical regulators of innate immunity and antiviral response. Tripartite Motif-containing 7 (Trim7), which upon Ras-Raf-MEK-ERK pathway activation, is phosphorylated and activated by MSK1. Trim7 in turn ubiquitinates and stabilises RACO-1, leading to increased c-Jun transcription. TRIM7 is involved in protein ubiquitination and thus regulating cellular proliferation. TRIM7 is upregulated in advanced carotid atherosclerosis (AS). TRIM7 overexpression may contribute to the highly proliferative characteristics of hepatocellular carcinoma (HCC) cells, and targeting TRIM7 might be a potential strategy for HCC treatment.
References
Ji R, et al. (2020) Trim7 promotes proliferation and migration of vascular smooth muscle cells in atherosclerosis through activating c-jun/ap-1. IUBMB Life 72 (2): 247-258.Hu X, et al. (2019) Tripartite motif-containing protein 7 regulates hepatocellular carcinoma cell proliferation via the dusp6/p38 pathway. Biochem Biophys Res Commun 511 (4): 889-895.Chakraborty A, et al. (2015) The e3 ubiquitin ligase trim7 mediates c-jun/ap-1 activation by ras signalling. Nat Commun 6 6782.
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Product Notes
The TRIM7 (Catalog #AAA8110110) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TRIM7 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TRIM7 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:200-1:1000. Researchers should empirically determine the suitability of the TRIM7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRIM7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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