SDS-PAGE
BAMBI / NMA recombinant protein
Recombinant Human BAMBI / NMA Protein (His tag)
SDS-PAGE
SDS-PAGE
Description: A DNA sequence encoding the human BAMBI extracellular domain (NP_036474.1) (Met 1-Ala 152) was expressed, fused with a C-terminal polyhistidine tag.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
Uniprot Description
BAMBI: Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.
Protein type: Inhibitor; Membrane protein, integral
Chromosomal Location of Human Ortholog: 10p12.1
Cellular Component: cytoplasm; plasma membrane
Molecular Function: frizzled binding; punt binding
Biological Process: cell migration; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of protein binding; positive regulation of transcription, DNA-dependent; regulation of cell shape
Research Articles on BAMBI / NMA
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Product Notes
The BAMBI / NMA bambi (Catalog #AAA2546027) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The secreted recombinant human BAMBI comprises 143 amino acids with a predicted molecular mass of 16.1 kDa. As a result of different glycosylation, the apparent molecular mass of rh BAMBI is approximately 16-23 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the BAMBI / NMA bambi for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BAMBI / NMA, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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