Rabbit anti-Human TRIAP1 Polyclonal Antibody | anti-TRIAP1 antibody

TRIAP1 Antibody

Cat. Num. AAA7045385

• Gene Names: TRIAP1; WF-1; MDM35; P53CSV; HSPC132
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: TRIAP1; Polyclonal Antibody; TRIAP1 Antibody; TP53-regulated inhibitor of apoptosis 1; Protein 15E1.1; WF-1; p53-inducible cell-survival factor; p53CSV; 15E1.1; HSPC132; anti-TRIAP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 76

• Applicable Applications for anti-TRIAP1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC: 1:20-1:200
• Species: Human
• Immunogen: Recombinant human TP53-regulated inhibitor of apoptosis 1 protein (1-76AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-139542 / sc-139543 / sc-139544
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human small intestine using MBS7045385 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS7045385 at dilution 1:100)

Related Product Information for anti-TRIAP1 antibody

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).

NCBI and Uniprot Product Information

• NCBI GI #: 7705467
• NCBI GeneID: 51499
• NCBI Accession #: NP_057483.1
• NCBI GenBank Nucleotide #: NM_016399.2
• UniProt Accession #: O43715; Q5RKS5; Q6LCA7; B2R4Z7
• Molecular Weight: 8,786 Da
• NCBI Official Full Name: TP53-regulated inhibitor of apoptosis 1
• NCBI Official Synonym Full Names: TP53 regulated inhibitor of apoptosis 1
• NCBI Official Symbol: TRIAP1
• NCBI Official Synonym Symbols: WF-1; MDM35; P53CSV; HSPC132
• NCBI Protein Information: TP53-regulated inhibitor of apoptosis 1
• UniProt Protein Name: TP53-regulated inhibitor of apoptosis 1
• Protein Family: TP53-regulated inhibitor of apoptosis
• UniProt Gene Name: TRIAP1
• UniProt Synonym Gene Names: 15E1.1; p53CSV
• UniProt Entry Name: TRIA1_HUMAN

Uniprot Description

TRIAP1: Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. Belongs to the TRIAP1/MDM35 family.

Protein type: Mitochondrial; Apoptosis; Inhibitor

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: mitochondrial intermembrane space; mitochondrion; protein complex

Molecular Function: p53 binding; protein binding

Biological Process: DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of apoptosis; negative regulation of caspase activity; phospholipid transport; positive regulation of transcription from RNA polymerase II promoter; regulation of apoptosis