Rabbit TRBP2 Polyclonal Antibody | anti-TARBP2 antibody
TRBP2 (Trans Activation Responsive RNA Binding Protein 2, Tar (HIV-1) RNA Binding Protein 2, TAR RNA Binding Protein 2, TARBP2, TRBP)
Purified by peptide immunoaffinity chromatography.
Purified by peptide immunoaffinity chromatography.
NCBI and Uniprot Product Information
NCBI Description
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq]
Uniprot Description
TRBP: the HIV-1 TAR RNA binding protein (TRBP) is a double strand RNA binding protein (dsRBP) that is required for the recruitment of Ago2 to the small interfering RNA (siRNA) bound by Dicer. TRBP increases HIV-1 expression and replication by inhibiting the interferon-induced protein kinase PKR and by increasing translation of viral mRNA. Dicer, Ago2, and TRBP are the main components of the RNA-induced silencing complex (RISC).
Protein type: Motility/polarity/chemotaxis; Translation; RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; miRNA binding; siRNA binding; protein homodimerization activity; double-stranded RNA binding
Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of translation; positive regulation of viral genome replication; regulation of transcription, DNA-dependent; pre-microRNA processing; regulation of viral transcription; RNA interference, targeting of mRNA for destruction; miRNA-mediated gene silencing, miRNA loading onto RISC; negative regulation of protein kinase activity; gene expression; negative regulation of defense response to virus by host; RNA interference, production of siRNA
Research Articles on TARBP2
Similar Products
Product Notes
The TARBP2 tarbp2 (Catalog #AAA622521) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TRBP2 (Trans Activation Responsive RNA Binding Protein 2, Tar (HIV-1) RNA Binding Protein 2, TAR RNA Binding Protein 2, TARBP2, TRBP) reacts with Bovine, Human, Mouse, Rat0 and may cross-react with other species as described in the data sheet. AAA Biotech's TRBP2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA). Suitable for use in ELISA. Researchers should empirically determine the suitability of the TARBP2 tarbp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRBP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
