Human RISC-loading complex subunit TARBP2 ELISA Kit | TARBP2 elisa kit

Human RISC-loading complex subunit TARBP2 ELISA Kit

Cat. Num. AAA2881610

• Gene Names: TARBP2; LOQS; TRBP; TRBP1; TRBP2
• Reactivity: Human
• Synonyms: RISC-loading complex subunit TARBP2; Human RISC-loading complex subunit TARBP2 ELISA Kit; TAR RNA-binding protein 2; Trans-activation-responsive RNA-binding protein; TARBP2; TRBP; TARBP2 elisa kit

• Reactivity: Human
• Sequence Length: 345

• Assay Type: Sandwich
• Detection Range: 0.312-20 ng/mL.
• Sensitivity: 0.19ng/mL
• Intra-Assay CV: <=6.0%
• Inter-Assay CV: <=11.3%
• Recovery: 114%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 19743838
• NCBI GeneID: 6895
• NCBI Accession #: NP_004169.3
• NCBI GenBank Nucleotide #: NM_004178.4
• UniProt Accession #: Q15633; Q12878; Q8WY32; Q8WY33; Q9BRY2
• Molecular Weight: 36,916 Da
• NCBI Official Full Name: RISC-loading complex subunit TARBP2 isoform b
• NCBI Official Synonym Full Names: TAR (HIV-1) RNA binding protein 2
• NCBI Official Symbol: TARBP2
• NCBI Official Synonym Symbols: LOQS; TRBP; TRBP1; TRBP2
• NCBI Protein Information: RISC-loading complex subunit TARBP2
• UniProt Protein Name: RISC-loading complex subunit TARBP2
• Protein Family: RISC-loading complex
• UniProt Gene Name: TARBP2
• UniProt Entry Name: TRBP2_HUMAN

NCBI Description

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]

Uniprot Description

TRBP: the HIV-1 TAR RNA binding protein (TRBP) is a double strand RNA binding protein (dsRBP) that is required for the recruitment of Ago2 to the small interfering RNA (siRNA) bound by Dicer. TRBP increases HIV-1 expression and replication by inhibiting the interferon-induced protein kinase PKR and by increasing translation of viral mRNA. Dicer, Ago2, and TRBP are the main components of the RNA-induced silencing complex (RISC).

Protein type: Translation; RNA processing; Motility/polarity/chemotaxis; RNA-binding

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cytoplasm; cytosol; nucleus; perinuclear region of cytoplasm

Molecular Function: double-stranded RNA binding; enzyme binding; miRNA binding; protein binding; protein homodimerization activity; protein N-terminus binding; siRNA binding

Biological Process: gene expression; miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, production of miRNAs; multicellular organism growth; negative regulation of defense response to virus by host; negative regulation of protein kinase activity; positive regulation of translation; positive regulation of viral genome replication; pre-microRNA processing; regulation of viral transcription; RNA interference, production of siRNA; RNA interference, siRNA loading onto RISC; RNA interference, targeting of mRNA for destruction; RNA-mediated gene silencing; single fertilization; spermatid development