Western Blot (WB)
(Western Blot: Sample: Human HepG2 cell lysate; Primary Ab: 1ug/ml Rabbit Anti-Mouse TGFbR2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Rabbit anti-Mouse Transforming Growth Factor Beta Receptor II Polyclonal Antibody | anti-TGFbR2 antibody
Polyclonal Antibody to Transforming Growth Factor Beta Receptor II (TGFbR2)
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user
Store at 4ºC for frequent use.
Aliquot and store at -20ºC for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition
Western Blot (WB)
(Western Blot: Sample: Human HepG2 cell lysate; Primary Ab: 1ug/ml Rabbit Anti-Mouse TGFbR2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Human HepG2 cell lysate; Primary Ab: 1ug/ml Rabbit Anti-Mouse TGFbR2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Mouse Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Mouse Tissue))
NCBI and Uniprot Product Information
Uniprot Description
TGFBR2: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer.
Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily
Chromosomal Location of Human Ortholog: 9 F3|9 68.39 cM
Cellular Component: caveola; cell surface; cytoplasm; cytosol; external side of plasma membrane; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; plasma membrane; receptor complex
Molecular Function: ATP binding; glycosaminoglycan binding; kinase activity; metal ion binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor activity; signal transducer, downstream of receptor, with serine/threonine kinase activity; SMAD binding; transferase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity, type II; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity; type I transforming growth factor beta receptor binding; type III transforming growth factor beta receptor binding
Biological Process: activation of protein kinase activity; apoptosis; atrioventricular valve morphogenesis; brain development; branching involved in blood vessel morphogenesis; cardiac left ventricle morphogenesis; cartilage development; cell differentiation; cell proliferation involved in endocardial cushion morphogenesis; common-partner SMAD protein phosphorylation; embryonic cranial skeleton morphogenesis; embryonic hemopoiesis; endocardial cushion fusion; gastrulation; growth plate cartilage chondrocyte growth; growth plate cartilage development; heart development; heart looping; in utero embryonic development; inferior endocardial cushion morphogenesis; lens development in camera-type eye; lung development; membranous septum morphogenesis; myeloid dendritic cell differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of cell proliferation; Notch signaling pathway; organ morphogenesis; outflow tract morphogenesis; outflow tract septum morphogenesis; palate development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of B cell tolerance induction; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of mesenchymal cell proliferation; positive regulation of NK T cell differentiation; positive regulation of reactive oxygen species metabolic process; positive regulation of smooth muscle cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; receptor-mediated endocytosis; regulation of cell proliferation; regulation of gene expression; regulation of growth; response to drug; smoothened signaling pathway; superior endocardial cushion morphogenesis; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; tricuspid valve morphogenesis; vasculogenesis
Research Articles on TGFbR2
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Product Notes
The TGFbR2 tgfbr2 (Catalog #AAA2027588) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Transforming Growth Factor Beta Receptor II (TGFbR2) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Transforming Growth Factor Beta Receptor II can be used in a range of immunoassay formats including, but not limited to, WB; IHC; ICC; IP. Western blotting: 0.5-2ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the TGFbR2 tgfbr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Transforming Growth Factor Beta Receptor II, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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