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Immunohistochemistry (IHC) (Anti-TEP1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Rabbit TP1 / TEP1 Polyclonal Antibody | anti-TP1 antibody

Rabbit Polyclonal to Human TP1 / TEP1

Gene Names
TEP1; TP1; TLP1; p240; TROVE1; VAULT2
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Purity
Immunoaffinity Purified
Synonyms
TP1 / TEP1; Polyclonal Antibody; Rabbit Polyclonal to Human TP1 / TEP1; Anti-TP1 / TEP1 Antibody (N-Terminus) IHC-plus; TEP1; p80 telomerase homolog; Telomerase protein 1; TLP1; TROVE domain family; member 1; TROVE1; VAULT2; p240; Telomerase protein component 1; TP1; Human TP1; anti-TP1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
20 amino acid peptide from near the amino terminus of human TP1.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.02% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
2627
Applicable Applications for anti-TP1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes
IHC-P (5 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
Target Species
Human
Immunogen Description
Synthetic peptide from human TEP1.
Immunogen Type
Synthetic peptide
Immunogen
TP1 / TEP1 antibody was raised against synthetic peptide from human TEP1.
Antigen Modification
N-Terminus
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-TEP1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC) (Anti-TEP1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-TEP1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC) (Anti-TEP1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of TP-1 in Human Lung cells with TP-1 antibody at 20 ug/ml.)

Immunofluorescence (IF) (Immunofluorescence of TP-1 in Human Lung cells with TP-1 antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot of TP1 in human kidney tissue lysate with TP1 antibody at (A) 1 and (B) 2 ug/ml.)

Western Blot (WB) (Western blot of TP1 in human kidney tissue lysate with TP1 antibody at (A) 1 and (B) 2 ug/ml.)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
289,578 Da
NCBI Official Full Name
telomerase protein component 1
NCBI Official Synonym Full Names
telomerase-associated protein 1
NCBI Official Symbol
TEP1
NCBI Official Synonym Symbols
TP1; TLP1; p240; TROVE1; VAULT2
NCBI Protein Information
telomerase protein component 1; telomerase protein 1; p80 telomerase homolog; TROVE domain family, member 1
UniProt Protein Name
Telomerase protein component 1
UniProt Gene Name
TEP1
UniProt Synonym Gene Names
TLP1; TP1; Telomerase protein 1
UniProt Entry Name
TEP1_HUMAN

NCBI Description

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. [provided by RefSeq, Jul 2008]

Uniprot Description

TEP1: Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: chromosome, telomeric region; nuclear matrix; cytoplasm; telomerase holoenzyme complex; ribonucleoprotein complex

Molecular Function: telomerase activity; RNA binding; ATP binding

Biological Process: RNA-dependent DNA replication; telomere maintenance via recombination

Research Articles on TP1

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Product Notes

The TP1 tep1 (Catalog #AAA240321) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human TP1 / TEP1 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TP1 / TEP1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB). IHC-P (5 ug/ml), WB Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.. Researchers should empirically determine the suitability of the TP1 tep1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TP1 / TEP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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