Western Blot (WB)
(Host: RabbitTarget Name: TOX3Sample Type: 293T Whole Cell lysatesAntibody Dilution: 1.0ug/ml)
Rabbit anti-Human TOX3 Polyclonal Antibody | anti-TOX3 antibody
TOX3 Antibody - N-terminal region
Western Blot (WB)
(Host: RabbitTarget Name: TOX3Sample Type: 293T Whole Cell lysatesAntibody Dilution: 1.0ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: TOX3Sample Type: 293T Whole Cell lysatesAntibody Dilution: 1.0ug/ml)
Target Description: The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
Uniprot Description
TOX3: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 16q12.1
Molecular Function: chromatin binding; estrogen response element binding; phosphoprotein binding; protein binding; protein homodimerization activity
Biological Process: negative regulation of neuron apoptosis; positive regulation of transcription, DNA-dependent
Research Articles on TOX3
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Product Notes
The TOX3 tox3 (Catalog #AAA3207897) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TOX3 Antibody - N-terminal region reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TOX3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TOX3 tox3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: MKCQPRSGAR RIEERLHYLI TTYLKFGNNN NYMNMAEANN AFFAASETFH. It is sometimes possible for the material contained within the vial of "TOX3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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