Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/35,)
Rabbit anti-Human BAZ1B Polyclonal Antibody | anti-BAZ1B antibody
BAZ1B Antibody
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/35,)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/35,)
NCBI and Uniprot Product Information
Uniprot Description
WSTF: plays a central role in chromatin remodeling and acts as a transcription regulator. Apparently possesses tyrosine-protein kinase activity, but bears no sequence resemblance classical tyrosine kinase proteins. Involved in DNA damage response by phosphorylating Y142 of histone H2AX. H2AXpY142 plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at Y142, and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. In the WINAC complex, plays an essential role by targeting the complex to acetylated histones, an essential step for VDR-promoter association. Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA. Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary. Two alternatively-spliced human isoforms have been reported.
Protein type: ATYPICAL group; BAZ family; DNA replication; EC 2.7.10.2; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: nuclear replication fork; nucleoplasm
Molecular Function: chromatin binding; histone kinase activity; protein binding; protein-tyrosine kinase activity
Biological Process: chromatin-mediated maintenance of transcription; double-strand break repair; heart morphogenesis; histone phosphorylation; positive regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent; response to DNA damage stimulus
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Product Notes
The BAZ1B baz1b (Catalog #AAA9416140) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BAZ1B Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BAZ1B can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:45-1:300. Researchers should empirically determine the suitability of the BAZ1B baz1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BAZ1B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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