Rabbit TOMM22 Polyclonal Antibody | anti-TOMM22 antibody

Phospho-TOMM22 (Ser43) Antibody

Cat. Num. AAA9612599

• Gene Names: TOMM22; 1C9-2; TOM22; MST065; MSTP065
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
• Synonyms: TOMM22; Polyclonal Antibody; Phospho-TOMM22 (Ser43) Antibody; anti-TOMM22 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Phospho-TOMM22 (Ser43) Antibody detects endogenous levels of TOMM22 only when phosphorylated at Ser43.; Tissue Specificity: Ubiquitous.
• Purity/Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-TOMM22 antibody: Peptide ELISA (EIA)
• Application Notes: Peptide ELISA: 1:20,000-1:40,000
• Immunogen: A synthesized peptide derived from human TOMM22 around the phosphorylation site of Ser43.
• Conjugation: Unconjugated
• Fragment: Fab fragment
• Subunit Structure: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOMM40. Interacts with PPP2R2B (By similarity).
• Similarity: Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins.Belongs to the Tom22 family.
• Subcellular Location: Mitochondrion outer membrane>Single-pass membrane protein.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Related Product Information for anti-TOMM22 antibody

Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 24212074
• NCBI GeneID: 56993
• UniProt Accession #: Q9NS69
• Molecular Weight: 142
• NCBI Official Full Name: Mitochondrial import receptor subunit TOM22 homolog
• NCBI Official Synonym Full Names: translocase of outer mitochondrial membrane 22 homolog (yeast)
• NCBI Official Symbol: TOMM22
• NCBI Official Synonym Symbols: 1C9-2; TOM22; MST065; MSTP065
• NCBI Protein Information: mitochondrial import receptor subunit TOM22 homolog; mitochondrial import receptor Tom22; translocase of outer membrane 22 kDa subunit homolog
• UniProt Protein Name: Mitochondrial import receptor subunit TOM22 homolog
• UniProt Gene Name: TOMM22
• UniProt Synonym Gene Names: TOM22; hTom22
• UniProt Entry Name: TOM22_HUMAN

NCBI Description

The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008]

Uniprot Description

TOMM22: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. Belongs to the Tom22 family.

Protein type: Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: mitochondrion; membrane; mitochondrial outer membrane translocase complex; mitochondrial inner membrane; integral to membrane

Molecular Function: protein binding; protein transmembrane transporter activity

Biological Process: cellular protein metabolic process; protein targeting to mitochondrion; protein import into mitochondrial outer membrane