Rabbit Toll-like Receptor 1 (TLR1) Polyclonal Antibody | anti-TLR1 antibody

Toll-like Receptor 1 (TLR1) Polyclonal Antibody

Cat. Num. AAA194446

• Gene Names: TLR1; TIL; CD281; rsc786; KIAA0012; MGC104956; MGC126311; MGC126312; TIL. LPRS5; DKFZp547I0610; DKFZp564I0682
• Applications: Western Blot, Immunohistochemistry
• Synonyms: Toll-like Receptor 1 (TLR1); Polyclonal Antibody; Toll-like Receptor 1 (TLR1) Polyclonal Antibody; anti-TLR1 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Toll-like Receptor 1 (TLR1) [Rabbit polyclonal antibody to human and mouse TLR1]; This antibody recognizes human and mouse TLR1.
• Form/Format: 50ug purified by ion-exchange chromatography in PBS containing 0.02% sodium azide.
• Sequence Length: 786

• Applicable Applications for anti-TLR1 antibody: Western Blot, Immunohistochemistry
• Application Notes: Western Blotting: use at 1-2ug/ml. A band of approximately 84 kDa is detected.; Immunohistochemistry: formalin-fixed, paraffin-embedded tissues, use at 5ug/ml.
• Antigen: Synthetic peptide corresponding to 16 amino acids near the amino terminus of human TLR1.
• Preservatives: 0.02% sodium azide
• Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: This antibody is stable at 4 degree C (short-term) or -70 degree C (long-term).

Immunohistochemistry

Related Product Information for anti-TLR1 antibody

TLR1 is a 786 amino acid protein with 18 N-terminal leucine-rich repeat motifs (LRRs) and a calculated molecular weight of 84 kDa. TLR1 is most closely related to TLR6 and TLR10 with 68% and 48% overall sequence identity, respectively. In vivo, two different sized transcripts for TLR1 are observed suggesting that the mRNA is alternatively spliced to generate two different forms of the protein. TLR1 mRNA is ubiquitously expressed and found at higher levels than the other TLRs. Of the major leukocyte populations, TLR1 is most highly expressed by monocytes, but is also expressed by macrophages, dendritic cells (DCs), polymorphonuclear leukocytes, B, T, and NK cells.

Product Categories/Family for anti-TLR1 antibody

Neuroscience and Signal Transduction Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 2459618
• NCBI GeneID: 7096
• UniProt Accession #: Q15399; O15452; Q32MK3; Q9UG90; Q32MK4; Q5FWG5; Q6FI64
• Molecular Weight: 90,291 Da
• NCBI Official Full Name: Toll-like receptor 1
• NCBI Official Synonym Full Names: toll-like receptor 1
• NCBI Official Symbol: TLR1
• NCBI Official Synonym Symbols: TIL; CD281; rsc786; KIAA0012; MGC104956; MGC126311; MGC126312; TIL. LPRS5; DKFZp547I0610; DKFZp564I0682
• NCBI Protein Information: toll-like receptor 1; OTTHUMP00000218158; OTTHUMP00000218173; OTTHUMP00000218175; toll/interleukin-1 receptor-like protein
• UniProt Protein Name: Toll-like receptor 1
• Protein Family: Toll-like receptor
• UniProt Gene Name: TLR1
• UniProt Synonym Gene Names: KIAA0012
• UniProt Entry Name: TLR1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq]

Uniprot Description

TLR1: Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Binds MYD88 (via TIR domain). Interacts with CNPY3. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: phagocytic vesicle membrane; membrane; integral to plasma membrane; plasma membrane

Molecular Function: transmembrane receptor activity; protein heterodimerization activity; receptor activity

Biological Process: MyD88-dependent toll-like receptor signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; regulation of cytokine secretion; macrophage activation; positive regulation of interleukin-6 biosynthetic process; innate immune response; immune response; detection of triacylated bacterial lipoprotein; inflammatory response; signal transduction; toll-like receptor 1 signaling pathway

Disease: Leprosy, Susceptibility To, 5