Immunohistochemistry (IHC)
(Immunochemical staining of human TNIP3 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human TNIP3 Polyclonal Antibody | anti-TNIP3 antibody
Anti-TNIP3 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
TNIP3; Polyclonal Antibody; Anti-TNIP3 Antibody; Rabbit Polyclonal; TNIP3 Antibody; Rabbit PAb; Antigen Affinity Purified; TNFAIP3 interacting protein 3; Anti-ABIN-3 Antibody; Anti-LIND Antibody; anti-TNIP3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human TNIP3
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-TNIP3 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human TNIP3 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human TNIP3 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human TNIP3 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human TNIP3 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-TNIP3 antibody
TNIP3 (TNFAIP3 Interacting Protein 3) is a Protein Coding gene. The TNIP3 gene, located on 4q27, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. TNIP3 binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1, and 12-O-tetradecanoylphorbol-13-acetate. The overexpression of TNIP3 inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. TNIP3 may be a promising therapeutic target for nonalcoholic steatohepatitis (NASH) management. Diseases associated with TNIP3 include Inflammatory Bowel Disease 2. Among its related pathways are Ovarian tumor domain proteases and the Metabolism of proteins.
References
Staege H, et al. (2001) Two novel genes find and lind differentially expressed in deactivated and listeria-infected human macrophages. Immunogenetics 53 (2): 105-113.Liu D, et al. (2020) Tnfaip3 interacting protein 3 overexpression suppresses nonalcoholic steatohepatitis by blocking tak1 activation. Cell Metab 31 (4): 726-740.e728.Huang KW, et al. (2019) Elevated tnip3 mrna expression in tnf-alpha-secreting cells from patients with major depressive disorder. Neuroimmunomodulation 26 (3): 153-158.
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Product Notes
The TNIP3 (Catalog #AAA8109381) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TNIP3 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TNIP3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the TNIP3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNIP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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