Western Blot (WB)
(TNFRSF6B Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TNFRSF6B antibody detected the TNFRSF6B protein (arrow).)
Rabbit anti-Human TNFRSF6B Polyclonal Antibody | anti-TNFRSF6B antibody
TNFRSF6B Antibody (N-term)
Western Blot (WB)
(TNFRSF6B Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TNFRSF6B antibody detected the TNFRSF6B protein (arrow).)
Western Blot (WB)
(TNFRSF6B Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TNFRSF6B antibody detected the TNFRSF6B protein (arrow).)
Immunohistochemistry (IHC)
(TNFRSF6B antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TNFRSF6B antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(TNFRSF6B antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TNFRSF6B antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Flow Cytometry (FC/FACS)
(TNFRSF6B Antibody (N-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(TNFRSF6B Antibody (N-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
superfamily. The encoded protein is postulated to play a regulatory
role in suppressing FasL- and LIGHT-mediated cell death. It acts as
a decoy receptor that competes with death receptors for ligand
binding. Overexpression of this gene has been noted in
gastrointestinal tract tumors, and it is located in a gene-rich
cluster on chromosome 20, with other potentially tumor-related
genes. Two transcript variants encoding the same isoform, but
differing in the 5' UTR, have been observed for this gene.
Xiong, G., et al. Tumour Biol. 31(5):443-449(2010)
Sung, H.Y., et al. Int. J. Radiat. Biol. 86(9):780-790(2010)
Brunetti, G., et al. Ann. N. Y. Acad. Sci. 1192, 298-302 (2010) :
Perdigones, N., et al. Arthritis Rheum. 62(3):705-710(2010)
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Uniprot Description
TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20q13.3
Cellular Component: extracellular space
Molecular Function: protein binding; receptor activity
Biological Process: apoptosis; negative regulation of apoptosis
Research Articles on TNFRSF6B
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Product Notes
The TNFRSF6B tnfrsf6b (Catalog #AAA9207685) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 22-48. The TNFRSF6B Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TNFRSF6B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the TNFRSF6B tnfrsf6b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNFRSF6B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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