Rabbit anti-Human TNFRSF21 Polyclonal Antibody | anti-TNFRSF21 antibody

TNFRSF21 Antibody

Cat. Num. AAA1497608

• Gene Names: TNFRSF21; DR6; CD358; BM-018
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: TNFRSF21; Polyclonal Antibody; TNFRSF21 Antibody; Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358); DR6; anti-TNFRSF21 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid

• Applicable Applications for anti-TNFRSF21 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB:1:200-1:1000, IHC:1:20-1:200
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Conjugate: Non-conjugated
• Species: Human
• Research Area: Cell Biology
• Immunogen: Recombinant Human Tumor necrosis factor receptor superfamily member 21 protein (371-655AA)
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-5866 / sc-13106 / sc-25772
• Preparation and Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: TNFRSF21 antibody at 4ug/mlLane 1:K562 whole cell lysateLane 2: Jurkat whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 72kDaObserved band size: 72kDa)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreas using MBS1497608 at dilution 1:100)

Related Product Information for anti-TNFRSF21 antibody

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.

NCBI and Uniprot Product Information

• NCBI GI #: 7657039
• NCBI GeneID: 27242
• NCBI Accession #: NP_055267.1
• NCBI GenBank Nucleotide #: NM_014452.4
• UniProt Accession #: O75509; Q0D2P5; Q96D86; B2RDI9
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 21
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily member 21
• NCBI Official Symbol: TNFRSF21
• NCBI Official Synonym Symbols: DR6; CD358; BM-018
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 21
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 21
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF21
• UniProt Synonym Gene Names: DR6
• UniProt Entry Name: TNR21_HUMAN

NCBI Description

This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]

Uniprot Description

DR6: May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Associates with TRADD. Interacts with N-APP. Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.

Protein type: Receptor, cytokine; Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: axon; integral to plasma membrane; intrinsic to plasma membrane; plasma membrane

Molecular Function: protein binding; tumor necrosis factor receptor activity

Biological Process: adaptive immune response; apoptosis; B cell apoptosis; cellular lipid metabolic process; humoral immune response; immune response; inflammatory response; myelination; negative regulation of B cell proliferation; negative regulation of myelination; negative regulation of T cell proliferation; neuron apoptosis; regulation of apoptosis; regulation of cell proliferation; regulation of oligodendrocyte differentiation; response to lipopolysaccharide; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway