Rabbit anti-Human TNFRSF10C Polyclonal Antibody | anti-TNFRSF10C antibody

Rabbit Anti Human TNFRSF10C PolyClonal Antibody

Cat. Num. AAA1491074

• Gene Names: TNFRSF10C; LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: TNFRSF10C; Polyclonal Antibody; Rabbit Anti Human TNFRSF10C PolyClonal Antibody; LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR; anti-TNFRSF10C antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Sequence Length: 259

• Applicable Applications for anti-TNFRSF10C antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Recombinant protein of human TNFRSF10C
• Relevance: The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems. The receptors are activated by a family of cytokines that include TNF, FasL, and TRAIL. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases.Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2 and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand. Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity.
• Storage Buffer: Store at -20 degree C or -80 degree C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

NCBI and Uniprot Product Information

• NCBI GI #: 22547121
• NCBI GeneID: 8794
• NCBI Accession #: NP_003832.2
• NCBI GenBank Nucleotide #: NM_003841.3
• Molecular Weight: 27,407 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 10C
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
• NCBI Official Symbol: TNFRSF10C
• NCBI Official Synonym Symbols: LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 10C; decoy receptor 1; cytotoxic TRAIL receptor-3; lymphocyte inhibitor of TRAIL; decoy TRAIL receptor without death domain; antagonist decoy receptor for TRAIL/Apo-2L; TNF-related apoptosis-inducing ligand receptor 3
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 10C
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF10C
• UniProt Synonym Gene Names: DCR1; LIT; TRAILR3; TRID; DcR1; TRAIL receptor 3; TRAIL-R3
• UniProt Entry Name: TR10C_HUMAN

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

Uniprot Description

TRAIL-R3: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 8p22-p21

Cellular Component: integral to plasma membrane

Molecular Function: transmembrane receptor activity; TRAIL binding

Biological Process: apoptosis; signal transduction