Rabbit anti-Human TNF receptor-associated factor 5 Polyclonal Antibody | anti-TRAF5 antibody

Rabbit anti-human TNF receptor-associated factor 5 polyclonal Antibody(TRAF5), HRP conjugated

Cat. Num. AAA1495667

• Gene Names: TRAF5; RNF84; MGC:39780
• Reactivity: Human
• Applications: ELISA
• Purity: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Synonyms: TNF receptor-associated factor 5; Polyclonal Antibody; Rabbit anti-human TNF receptor-associated factor 5 polyclonal Antibody(TRAF5); HRP conjugated; RING finger protein 84; RNF84; TRAF5; anti-TRAF5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Sequence Length: 557

• Applicable Applications for anti-TRAF5 antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: HRP
• Immunogen: Recombinant human TNF receptor-associated factor 5 protein(1-557AA)
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6195 / sc-7220
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-TRAF5 antibody

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

NCBI and Uniprot Product Information

• NCBI GI #: 77404348
• NCBI GeneID: 7188
• NCBI Accession #: NP_001029082.1
• NCBI GenBank Nucleotide #: NM_001033910.2
• UniProt Accession #: O00463; Q6FHY1; B4DIS9; B4E0A2
• Molecular Weight: 52,158 Da
• NCBI Official Full Name: TNF receptor-associated factor 5 isoform b
• NCBI Official Synonym Full Names: TNF receptor associated factor 5
• NCBI Official Symbol: TRAF5
• NCBI Official Synonym Symbols: RNF84; MGC:39780
• NCBI Protein Information: TNF receptor-associated factor 5
• UniProt Protein Name: TNF receptor-associated factor 5
• Protein Family: TNF receptor-associated factor
• UniProt Gene Name: TRAF5
• UniProt Synonym Gene Names: RNF84
• UniProt Entry Name: TRAF5_HUMAN

NCBI Description

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Uniprot Description

TRAF5: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Belongs to the TNF receptor-associated factor family. A subfamily.

Protein type: Adaptor/scaffold; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: centrosome; cytoplasm; cytosol; internal side of plasma membrane

Molecular Function: protein binding; signal transducer activity; thioesterase binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: activation of NF-kappaB transcription factor; apoptosis; positive regulation of cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor activity; protein ubiquitination; regulation of apoptosis; signal transduction