Goat TMPRSS11D/HAT Polyclonal Antibody | anti-TMPRSS11D antibody

Goat anti-TMPRSS11D/HAT Antibody

Cat. Num. AAA421933

• Gene Names: TMPRSS11D; HAT
• Reactivity: Expected from sequence similarity: Human
• Applications: ELISA
• Purity: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Synonyms: TMPRSS11D/HAT; Polyclonal Antibody; Goat anti-TMPRSS11D/HAT Antibody; TMPRSS11D; transmembrane protease; serine 11D; HAT; MGC150587; MGC150588; airway trypsin like protease; airway trypsin-like protease; TMPRSS11D antibody; serine 11D antibody; HAT antibody; MGC150587 antibody; MGC150588 antibody; airway trypsin like protease antibody; airway trypsin-like protease antibody; TMPRSS11D / HAT; anti-TMPRSS11D antibody

• Host: Goat
• Reactivity: Expected from sequence similarity: Human
• Clonality: Polyclonal
• Purity/Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Form/Format: Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: 100ug specific antibody in 200ul (varies by lot)
• Sequence: HNNYKSATHEND
• Sequence Length: 418

• Applicable Applications for anti-TMPRSS11D antibody: Peptide ELISA (EIA)
• Application Notes: Peptide ELISA: Antibody detection limit dilution 1: 8000.; Western Blot: Preliminary experiments gave an approx 20kDa band in lysates of HepG2 after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 46.3kDa according to NP_004253.1. The 20kDa band was successfully blocked by incubation with the immunizing peptide.
• Immunogen: Peptide with sequence C-HNNYKSATHEND, from the internal region of the protein sequence according to NP_004253.1.
• Epitope: Internal region
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 4758508
• NCBI GeneID: 9407
• NCBI Accession #: NP_004253.1
• NCBI GenBank Nucleotide #: NM_004262.2
• Molecular Weight: 46,263 Da
• NCBI Official Full Name: transmembrane protease serine 11D
• NCBI Official Synonym Full Names: transmembrane protease, serine 11D
• NCBI Official Symbol: TMPRSS11D
• NCBI Official Synonym Symbols: HAT
• NCBI Protein Information: transmembrane protease serine 11D
• UniProt Protein Name: Transmembrane protease serine 11D
• Protein Family: Transmembrane protease serine
• UniProt Gene Name: TMPRSS11D
• UniProt Synonym Gene Names: HAT
• UniProt Entry Name: TM11D_HUMAN

NCBI Description

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]

Uniprot Description

TMPRSS11D: May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.-; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 4q13.2

Cellular Component: extracellular region; integral to plasma membrane

Molecular Function: peptidase activity; serine-type endopeptidase activity

Biological Process: proteolysis; respiratory gaseous exchange