Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using TMPO antibody.)
Rabbit TMPO Polyclonal Antibody | anti-TMPO antibody
TMPO Polyclonal Antibody
IHC: 1:50-1:200
IF: 1:50-1:200
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using TMPO antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using TMPO antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat brain using TMPO Antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat brain using TMPO Antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cells using TMPO antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cells using TMPO antibody.)
NCBI and Uniprot Product Information
Observed: 56kDa
NCBI Description
The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010]
Uniprot Description
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.CautionTMPO was originally considered a good candidate for dilated cardiomyopathy, and variant Cys-290 has been reported to be a likely pathogenic mutation (PubMed:16247757). However, Cys-290 has a high allele frequency and individuals homozygous for the variant have been reported in ExAC database. Therefore, this variant has been reclassified as a likely benign polymorphism (PubMed:27896284).
Research Articles on TMPO
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Product Notes
The TMPO tmpo (Catalog #AAA2554171) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TMPO Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TMPO can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200. Researchers should empirically determine the suitability of the TMPO tmpo for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TMPO, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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