Rabbit anti-Mouse TMM18 Polyclonal Antibody | anti-TMM18 antibody

TMM18, ID (TMEM18, Transmembrane protein 18) (FITC)

Cat. Num. AAA6356573

• Reactivity: Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TMM18; Polyclonal Antibody; ID (TMEM18; Transmembrane protein 18) (FITC); TMEM18; Transmembrane protein 18; anti-TMM18 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-TMM18 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: TMM18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-90 amino acids from the Central region of human TMM18.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TMM18 Antibody (Center) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the TMM18 antibody detected the TMM18 protein (arrow).)

Immunohistochemistry (IHC)

(TMM18 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TMM18 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-TMM18 antibody

TMM18 is a cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).

Product Categories/Family for anti-TMM18 antibody

Antibodies; Transmembrane Proteins

References

Fontaine-Bisson, B., et al. Diabetologia 53(10):2155-2162(2010). Holzapfel, C., et al. Int J Obes (Lond) 34(10):1538-1545(2010). Holzapfel, C., et al. J Epidemiol Community Health (2010). In press: Elks, C.E., et al. PLoS Med. 7 (5), E1000284 (2010): Scherag, A., et al. PLoS Genet. 6 (4), E1000916 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 40548391
• NCBI GeneID: 129787
• NCBI Accession #: NP_690047.2
• NCBI GenBank Nucleotide #: NM_152834.2
• UniProt Accession #: Q96B42; Q8N5H2; Q9NTH3; D6W4X9
• Molecular Weight: 15,011 Da
• NCBI Official Full Name: transmembrane protein 18
• NCBI Official Synonym Full Names: transmembrane protein 18
• NCBI Official Symbol: TMEM18
• NCBI Protein Information: transmembrane protein 18
• UniProt Protein Name: Transmembrane protein 18
• UniProt Gene Name: TMEM18
• UniProt Entry Name: TMM18_HUMAN

Uniprot Description

TMEM18: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC). Belongs to the TMEM18 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p25.3

Cellular Component: nuclear membrane; cytoplasm; integral to membrane

Molecular Function: DNA binding

Biological Process: cell migration; transcription, DNA-dependent