Rabbit anti-Human TMIE Polyclonal Antibody | anti-TMIE antibody

TMIE, ID (TMIE, Transmembrane inner ear expressed protein)

Cat. Num. AAA6000326

• Gene Names: TMIE; DFNB6
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: TMIE; Polyclonal Antibody; ID (TMIE; Transmembrane inner ear expressed protein); Anti -TMIE; anti-TMIE antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-TMIE antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: TMIE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78~108 amino acids from the Central region of human TMIE.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of TMIE Antibody (Center) in mouse liver tissue lysates (35ug/lane). TMIE (arrow) was detected using the purified Pab.)

Related Product Information for anti-TMIE antibody

This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment.

Product Categories/Family for anti-TMIE antibody

Antibodies; Abs to Transmembrane Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 158631211
• NCBI GeneID: 259236
• NCBI Accession #: NP_671729.2
• NCBI GenBank Nucleotide #: NM_147196.2
• UniProt Accession #: Q8NEW7; A0AV93; A8K0R0
• Molecular Weight: 17,241 Da
• NCBI Official Full Name: transmembrane inner ear expressed protein
• NCBI Official Synonym Full Names: transmembrane inner ear
• NCBI Official Symbol: TMIE
• NCBI Official Synonym Symbols: DFNB6
• NCBI Protein Information: transmembrane inner ear expressed protein; transmembrane inner ear protein
• UniProt Protein Name: Transmembrane inner ear expressed protein
• Protein Family: Transmembrane inner ear expressed protein
• UniProt Gene Name: TMIE
• UniProt Entry Name: TMIE_HUMAN

NCBI Description

This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment. [provided by RefSeq, Mar 2009]

Uniprot Description

TMIE: Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain. Defects in TMIE are the cause of deafness autosomal recessive type 6 (DFNB6). DFNB6 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: integral to membrane

Biological Process: inner ear morphogenesis; sensory perception of sound

Disease: Deafness, Autosomal Recessive 6