Western Blot (WB)
(Western blot analysis of TMEM59L in rat heart tissue lysate with TMEM59L antibody at 1 μg/mL.)
Rabbit TMEM59L Polyclonal Antibody | anti-TMEM59L antibody
TMEM59L Antibody
Gene Names
TMEM59L; BSMAP; C19orf4
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
TMEM59L Antibody is affinity chromatography purified via peptide column.
Synonyms
TMEM59L; Polyclonal Antibody; TMEM59L Antibody; BSMAP; C19orf4; Transmembrane protein 59-like; Brain-specific membrane-anchored protein; transmembrane protein 59-like; anti-TMEM59L antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Multiple isoforms of TMEM59L are known to exist. TMEM59L antibody is predicted to not cross-react TMEM59.
Purity/Purification
TMEM59L Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
342
Applicable Applications for anti-TMEM59L antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
TMEM59L antibody can be used for detection of TMEM59L by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
Conjugate
Unconjugated
Immunogen
TMEM59L antibody was raised against a 19 amino acid synthetic peptide near carboxy terminus of human TMEM59L.
Buffer
TMEM59L Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
TMEM59L antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of TMEM59L in rat heart tissue lysate with TMEM59L antibody at 1 μg/mL.)
Western Blot (WB)
(Western blot analysis of TMEM59L in rat heart tissue lysate with TMEM59L antibody at 1 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of TMEM59L in mouse brain tissue with TMEM59L antibody at 2.5 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of TMEM59L in mouse brain tissue with TMEM59L antibody at 2.5 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of TMEM59L in mouse brain tissue with TMEM59L antibody at 20 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of TMEM59L in mouse brain tissue with TMEM59L antibody at 20 μg/mL.)
Related Product Information for anti-TMEM59L antibody
TMEM59L Antibody: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59L is a type I membrane glycoprotein that is expressed in the brain. A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
37,619 Da
NCBI Official Full Name
transmembrane protein 59-like
NCBI Official Synonym Full Names
transmembrane protein 59-like
NCBI Official Symbol
TMEM59L
NCBI Official Synonym Symbols
BSMAP; C19orf4
NCBI Protein Information
transmembrane protein 59-like; brain-specific membrane-anchored protein
UniProt Protein Name
Transmembrane protein 59-like
Protein Family
UniProt Gene Name
TMEM59L
UniProt Synonym Gene Names
BSMAP; C19orf4
UniProt Entry Name
TM59L_HUMAN
NCBI Description
This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]
Uniprot Description
TMEM59L: Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding. Belongs to the TMEM59 family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p12
Cellular Component: Golgi membrane; membrane; integral to membrane
Similar Products
Product Notes
The TMEM59L tmem59l (Catalog #AAA150749) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TMEM59L Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TMEM59L can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). TMEM59L antibody can be used for detection of TMEM59L by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the TMEM59L tmem59l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TMEM59L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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