Rabbit TMEM49 Polyclonal Antibody | anti-VMP1 antibody

TMEM49 Antibody

Cat. Num. AAA9629672

• Gene Names: VMP1; EPG3; TANGO5; TMEM49
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: TMEM49; Polyclonal Antibody; TMEM49 Antibody; DKFZP566I133; ectopic P-granules autophagy protein 3 homolog; NF E2 induceble protein 2; NF E2 inducible protein 2; ni 2; protein ni 2; Tango5; TDC1; Transmembrane protein 49; transport and golgi organization 5 homolog; Vacuole membrane protein 1; vmp1; VMP1_HUMAN; anti-VMP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: TMEM49 Antibody detects endogenous levels of total TMEM49.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-VMP1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain. Belongs to the VMP1 family.
• Subunit Structure: Interacts with BECN1 (By similarity). Interacts with TJP1. Interacts with TP53INP2. Interacts with TMEM41B.
• Function: Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Required for autophagosome formation.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-VMP1 antibody

Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein; Cell membrane; Vacuole membrane; Endoplasmic reticulum; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 20070349
• NCBI GeneID: 81671
• NCBI Accession #: NP_112200.2
• NCBI GenBank Nucleotide #: NM_030938.4
• UniProt Accession #: Q96GC9; Q9H0P4; Q9P089; B4DVV9
• Molecular Weight: 24,148 Da
• NCBI Official Full Name: vacuole membrane protein 1 isoform 1
• NCBI Official Synonym Full Names: vacuole membrane protein 1
• NCBI Official Symbol: VMP1
• NCBI Official Synonym Symbols: EPG3; TANGO5; TMEM49
• NCBI Protein Information: vacuole membrane protein 1
• UniProt Protein Name: Vacuole membrane protein 1
• Protein Family: Vacuole membrane protein
• UniProt Gene Name: VMP1
• UniProt Synonym Gene Names: TDC1; TMEM49

NCBI Description

This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]

Uniprot Description

Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions.