Rabbit TMEM16A Polyclonal Antibody | anti-TMEM16A antibody
TMEM16A Antibody BIOTIN-Conjugated
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500
Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
NCBI and Uniprot Product Information
Uniprot Description
ANO1: Acts as a calcium-activated chloride channel. Required for normal tracheal development. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transporter, ion channel; Transporter; Membrane protein, multi-pass
Cellular Component: apical plasma membrane; cytoplasm; external side of plasma membrane; integral to membrane; membrane; plasma membrane
Molecular Function: calcium activated cation channel activity; chloride channel activity; intracellular calcium activated chloride channel activity; iodide transmembrane transporter activity; phospholipid scramblase activity; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; voltage-gated chloride channel activity
Biological Process: cation transport; chloride transport; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); iodide transport; ion transport; multicellular organismal development; regulation of membrane potential; transport
Research Articles on TMEM16A
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Product Notes
The TMEM16A ano1 (Catalog #AAA5400110) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TMEM16A Antibody BIOTIN-Conjugated reacts with Monkey, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TMEM16A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Immunoprecipitation: 1:200 Western Blot: 1:500. Researchers should empirically determine the suitability of the TMEM16A ano1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TMEM16A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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