Western Blot (WB)
TMEM16A positive control
TMEM16A Antibody Positive Control
Gene Names
ANO1; DOG1; TAOS2; ORAOV2; TMEM16A
Applications
Western Blot
Synonyms
TMEM16A; TMEM16A Antibody Positive Control; ANO 1; Anoctamin 1; Anoctamin 1 calcium activated chloride channel; Ca2+ activated Cl- channel; Discovered on gastrointestinal stromal tumors protein 1; DOG 1; Membrane protein; Oral cancer overexpressed protein 2; ORAOV 2; TAOS2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2 antibody; TMEM16A positive control
Form/Format
Western Blot Positive Control
Sequence Length
986
Applicable Applications for TMEM16A positive control
Western Blot (WB)
Application Notes
Western Blot: 1:500
Immunogen
Purified Protein
Expression
Highly expressed in pulmonary bronchiole epithelial cells, pancreatic and submandibular gland acinar cells, kidney proximal tubule, all retinal cell layers, most sensory cells of dorsal root ganglia, Leydig cells and spermatocytes (at protein level). Expressed at high levels in the thyroid gland and gastrointestinal muscles.
Molecular Function
Chloride channel, Developmental protein, Ion channel
Structure
Homodimer. Interacts with CFTR (By similarity).
Subcellular Location
Cell membrane; Multi-pass membrane protein, Cytoplasm
Preparation and Storage
-20 degree C for long term storage
Western Blot (WB)
Western Blot (WB)
Related Product Information for TMEM16A positive control
Western Blot Positive Control Transmembrane protein 16A Antibody
Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
74,369 Da
NCBI Official Full Name
Anoctamin-1
NCBI Official Synonym Full Names
anoctamin 1
NCBI Official Symbol
ANO1
NCBI Official Synonym Symbols
DOG1; TAOS2; ORAOV2; TMEM16A
NCBI Protein Information
anoctamin-1
UniProt Protein Name
Anoctamin-1
UniProt Gene Name
ANO1
UniProt Synonym Gene Names
DOG1; ORAOV2; TAOS2; TMEM16A
UniProt Entry Name
ANO1_HUMAN
Uniprot Description
ANO1: Acts as a calcium-activated chloride channel. Required for normal tracheal development. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: apical plasma membrane; cytoplasm; plasma membrane
Molecular Function: calcium activated cation channel activity; chloride channel activity; intracellular calcium activated chloride channel activity; iodide transmembrane transporter activity; protein binding; protein dimerization activity; voltage-gated chloride channel activity
Biological Process: cation transport; chloride transport; detection of temperature stimulus involved in sensory perception of pain; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); iodide transport; multicellular organismal development
Research Articles on TMEM16A
1. Anoctamin and pendrin are two plausible candidates as mediators of apical iodide efflux--{review}
Similar Products
Product Notes
The TMEM16A ano1 (Catalog #AAA543330) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TMEM16A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the TMEM16A ano1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TMEM16A, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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