Western Blot (WB)
(Anti-TJP2 antibody, MBS176155, Western blottingLane 1: Rat Brain Tissue LysateLane 2: PC-12 Cell LysateLane 3: Mouse Brain Tissue LysateLane 4: HEPA Cell Lysate )
Rabbit anti-Mouse, Rat TJP2 Polyclonal Antibody | anti-TJP2 antibody
Anti-TJP2 antibody
Western Blot (WB)
(Anti-TJP2 antibody, MBS176155, Western blottingLane 1: Rat Brain Tissue LysateLane 2: PC-12 Cell LysateLane 3: Mouse Brain Tissue LysateLane 4: HEPA Cell Lysate )
Western Blot (WB)
(Anti-TJP2 antibody, MBS176155, Western blottingLane 1: Rat Brain Tissue LysateLane 2: PC-12 Cell LysateLane 3: Mouse Brain Tissue LysateLane 4: HEPA Cell Lysate )
Immunohistochemistry (IHC)
(Anti-TJP2 antibody, MBS176155, IHC(P)IHC(P): Mouse Liver Tissue )
Immunohistochemistry (IHC)
(Anti-TJP2 antibody, MBS176155, IHC(P)IHC(P): Mouse Liver Tissue )
Background: TJP2(Tight Junction Protein 2), also known as Zona Occludens 2 or ZO2, is a protein that in humans is encoded by the TJP2 gene. Tight junction proteins(TJPs) belong to a family of membrane-associated guanylate kinase(MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. Duclos et al.(1994) mapped the TJP2 gene telomeric to the Friedreich ataxia critical region on chromosome 9q13-q21. TJP2 lies about 70 kb centromeric to the X123 gene and is transcribed in the centromere-to-telomere direction. Using in vitro assays and immunoprecipitation studies, Itoh et al.(1999) showed that the mouse Tjp1, Tjp2, and Tjp3 PDZ1 domains interacted with the C-terminal cytoplasmic domains of Cldn1 through Cldn8. In the mouse inner ear, Walsh et al.(2010) found that Tjp2 expression decreased rapidly between E16.5 and age 1 week to a level in adult mice that was approximately 50% of the level at birth(P0).
NCBI and Uniprot Product Information
Uniprot Description
ZO2: a scaffolding protein of the MAGUK (membrane-associated guanylate kinase) family associated with epithelial tight junctions (TJ). May mediate dynamic changes in the composition of TJs. Plays a role in tight junctions and adherens junctions. Forms homodimers, and heterodimer with ZO-1 and ZO-3. The ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression. Interacts with occluding, UBN1 and scribble. Interacts with SAFB in the nucleus. TJ, or zonula occludens, are the closely associated areas of two cells whose membranes are tightly joined together. They are composed of a branching network of strands, the efficiency of which increases exponentially with the number of strands. The strands associate with transmembrane proteins that bind to similar proteins on adjacent cells, and with submembranous proteins that are anchored to the actin component of the cytoskeleton. Thus, TJs join together the cytoskeletons of adjacent cells. They endow tissues with substantial form, shape and location, enforce cellular polarity, and form barriers to molecules and pathogens. Molecules forming the membranous part of TJs include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules interact with the proteins ZO-1, ZO-2 and ZO-3. Tight junction proteins are involved in the epithelial-mesenchymal transitions (EMT) in tumors. Five isoforms of the human protein are produced by alternative promoters. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues..
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: tight junction; cell surface; membrane; cytoplasm; plasma membrane; gap junction; cell junction; nucleus
Molecular Function: protein C-terminus binding; protein binding, bridging; protein domain specific binding; protein binding
Biological Process: intestinal absorption
Research Articles on TJP2
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Product Notes
The TJP2 tjp2 (Catalog #AAA176155) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TJP2 antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TJP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the TJP2 tjp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TJP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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