Western Blot (WB)
(Western Blot analysis of TINAG expression in transfected 293T cell line by TINAG polyclonal antibody. Lane 1: TINAG transfected lysate (52.36kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human TINAG Polyclonal Antibody | anti-TINAG antibody
TINAG (Tubulointerstitial Nephritis Antigen, TIN-Ag)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of TINAG expression in transfected 293T cell line by TINAG polyclonal antibody. Lane 1: TINAG transfected lysate (52.36kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of TINAG expression in transfected 293T cell line by TINAG polyclonal antibody. Lane 1: TINAG transfected lysate (52.36kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]
Uniprot Description
Function: Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein. Ref.9
Subcellular location: Secreted › extracellular space › extracellular matrix › basement membrane Ref.2 Ref.7.
Tissue specificity: Expressed in the kidney cortex, small intestine and cornea. Ref.1 Ref.2 Ref.7
Developmental stage: Initially observed in the Bowman capsule during early glomerular capillary loop formation in the kidney. In more developmentally mature glomeruli, following transition from early to mid-capillary loop stage, expression is higher in the proximal tubular basement membrane than in the distal basement membrane and Bowman capsule. Ref.10
Post-translational modification: It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Miscellaneous: Antibodies against TINAG are found in sera of patients with tubulointerstitial nephritis, a rare autoimmune disorder that causes acute and chronic renal injury.
Sequence similarities: Belongs to the peptidase C1 family.Contains 1 SMB (somatomedin-B) domain.
Research Articles on TINAG
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Product Notes
The TINAG tinag (Catalog #AAA646530) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TINAG (Tubulointerstitial Nephritis Antigen, TIN-Ag) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TINAG can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the TINAG tinag for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MWTGYKILIF SYLTTEIWME KRYLSQREVD LEAYFTRNHT VLQGTRFKRA IFQGQYCRNF GCCEDRDDGC VTEFYAANAL CYCDKFCDRE NSDCCPDYKS FCREEKEWPP HTQPWYPEGC FKDGQHYEEG SVIKENCNSC TCSGQQWKCS QHVCLVRSEL IEQVNKGDYG WTAQNYSQFW GMTLEDGFKF RLGTLPPSLM LLSMNEMTAS LPATTDLPEF FVASYKWPGW THGPLDQKNC AASWAFSTAS VAADRIAIQS KGRYTANLSP QNLISCCAKN RHGCNSGSID RAWWYLRKRG LVSHACYPLF KDQNATNNGC AMASRSDGRG KRHATKPCPN NVEKSNRIYQ CSPPYRVSSN ETEIMKEIMQ NGPVQAIMQV HEDFFHYKTG IYRHVTSTNK ESEKYRKLQT HAVKLTGWGT LRGAQGQKEK FWIAANSWGK SWGENGYFRI LRGVNESDIE KLIIAAWGQL TSSDEP. It is sometimes possible for the material contained within the vial of "TINAG, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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